2018
DOI: 10.18632/aging.101616
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Abstract: Coronary microembolization (CME) substantially reduces the clinical benefits of myocardial reperfusion therapy. Autophagy and apoptosis participate in the pathophysiological processes of almost all cardiovascular diseases, including CME-induced myocardial injury, but the precise underlying mechanisms remain unclear. In the present study, we observed that Egr-1 expression was substantially increased after CME modeling. Inhibition of Egr-1 expression through the targeted delivery of rAAV9-Egr-1-shRNA improved ca… Show more

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Cited by 16 publications
(32 citation statements)
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References 37 publications
(32 reference statements)
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“…Cell apoptosis is an active programmed cell death mode under the control of the self‐gene and is different from the physiological death process of cell necrosis (Chimenti et al, ; Tian et al, ; Xu et al, ). Myocardial cell apoptosis is involved in many cardiovascular diseases (Salisbury‐Ruf et al, ; X. Wang et al, ; Yu et al, ). In this study, the apoptosis level of AngII injured cardiomyocytes increased significantly but irisin significantly reduced the apoptosis level of AngII‐injured cardiomyocytes.…”
Section: Discussionmentioning
confidence: 99%
“…Cell apoptosis is an active programmed cell death mode under the control of the self‐gene and is different from the physiological death process of cell necrosis (Chimenti et al, ; Tian et al, ; Xu et al, ). Myocardial cell apoptosis is involved in many cardiovascular diseases (Salisbury‐Ruf et al, ; X. Wang et al, ; Yu et al, ). In this study, the apoptosis level of AngII injured cardiomyocytes increased significantly but irisin significantly reduced the apoptosis level of AngII‐injured cardiomyocytes.…”
Section: Discussionmentioning
confidence: 99%
“…Egr1 and Egr2 belong to early growth response protein 1/2. They can induce myocardial injury by regulating myocardial autophagy, cell death, and the progression of myocardial fibrosis (Wang et al, 2018;Cao et al, 2010). Nr4a3, a member of the NR4A orphan nuclear receptor, plays a protective role during acute myocardial infarction by suppressing inflammatory responses via the JAK2-STAT3/NF-kB pathway (Obana et al, 2010;.…”
Section: Discussionmentioning
confidence: 99%
“…Studies have demonstrated that Egr-1 is regulated by miRNAs in several cardiovascular diseases [17,18]. In our previous study, we demonstrated that Egr-1 expression levels were increased and involved in the regulation of autophagy and apoptosis in a rat model for coronary microembolization [19]. However, whether miR-30e-3p regulates autophagy and apoptosis via the modulation of Egr-1 in IH-exposed cardiomyocytes is yet to be deciphered.…”
Section: Introductionmentioning
confidence: 90%