Egilman’s assessment regarding exposures of auto mechanics to amphiboles is not accurate

Paustenbach, Dennis J.; White, Katherine

doi:10.3109/08958378.2012.692126

Cited by 1 publication

(1 citation statement)

References 34 publications

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“…Epidemiology studies of occupationally exposed cohorts are less easy to interpret, with some studies or analyzes concluding that automobile mechanics have an elevated risk. Nonetheless, other studies and meta-analyzes indicate that mesothelioma risks are not significantly elevated (Aguilar-Madrid et al, 2010;Butnor et al, 2003;Dotson, 2006;Finley et al, 2012;Garabrant et al, 2016;Goodman et al, 2004;Hessel et al, 2004;Laden et al, 2004;Paustenbach & White, 2012;Peto et al, 2009;Rake et al, 2009;Richter et al, 2009;Teschke et al, 1997;Wong 2001Wong , 2006. This certainly does not mean that the incremental risks are zero.…”

Section: Mesotheliomamentioning

confidence: 99%

Review of refractory ceramic fiber (RCF) toxicity, epidemiology and occupational exposure

Maxim¹,

Utell

2018

Inhalation Toxicology

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This literature review on refractory ceramic fibers (RCF) summarizes relevant information on manufacturing, processing, applications, occupational exposure, toxicology and epidemiology studies. Rodent toxicology studies conducted in the 1980s showed that RCF caused fibrosis, lung cancer and mesothelioma. Interpretation of these studies was difficult for various reasons (e.g. overload in chronic inhalation bioassays), but spurred the development of a comprehensive product stewardship program under EPA and later OSHA oversight. Epidemiology studies (both morbidity and mortality) were undertaken to learn more about possible health effects resulting from occupational exposure. No chronic animal bioassay studies on RCF have been conducted since the 1980s. The results of the ongoing epidemiology studies confirm that occupational exposure to RCF is associated with the development of pleural plaques and minor decrements in lung function, but no interstitial fibrosis or incremental lung cancer. Evidence supporting a finding that urinary tumors are associated with RCF exposure remains, but is weaker. One reported, but unconfirmed, mesothelioma was found in an individual with prior occupational asbestos exposure. An elevated SMR for leukemia was found, but was absent in the highly exposed group and has not been observed in studies of other mineral fibers. The industry will continue the product stewardship program including the mortality study.

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