Egg-Shell Like Hollow Alumina Sphere Modified Electrode for Enhanced Electrochemical Determination of Metronidazole

Abstract

An egg shell like alumina hollow sphere was prepared using hydrothermally synthesised carbon sphere as hard template. Extensive studies have been carried out to characterize the alumina hollow sphere using different experimental techniques, such as FE-SEM, XRD, TGA, BET and electrochemical impedance spectroscopy (EIS). The electrochemical behavior of metronidazole (MNZ) drug was investigated using Al 2 O 3 hollow shell modified glassy carbon electrode (GCE) and a well-defined irreversible reduction peak was observed at −0.70V vs. Ag/AgCl at neutral pH medium. From the peak current against pH graph it is understand that the involvement of two protons and two electrons during reduction reaction and yield the corresponding hydroxylamine. Differential pulse voltamnmetry (DPV) method was employed for the electrochemical detection of metronidazole under optimized experimental condition. A linear calibration graph was drawn by plotting the peak current against concentration of MNZ ranging from 0.3 nM to 5.3 μM with a correlation coefficient of 0.9982. The detection limit was found to be 0.036 nM at a signal to noise (S/N) ratio of 3. The proposed method can be used for the electrochemical detection of metronidazole in real samples such as tablets and urine samples with greater sensitivity.

Metal‐free Sulfur‐doped graphitic carbon nitride‐modified GCE‐based electrocatalyst for the enhanced electrochemical determination of Omeprazole in Drug formulations and Biological Samples

“…The electrochemical methods are considered as an alternate instrumental method to overcome the above‐said obstacles. The low‐cost electrochemical techniques are appropriate for the quantitative determination of analytes due to their high sensitivity and lower detection limit 43–46 . In the present work, we developed a methodology based on sulfur‐doped graphitic carbon nitride as an electrode modifier to facilitate the electrochemical reaction, and thereby we can achieve higher sensitivity than the previously reported methods.…”

“…The low-cost electrochemical techniques are appropriate for the quantitative determination of analytes due to their high sensitivity and lower detection limit. [43][44][45][46] In the present work, we developed a methodology based on sulfur-doped graphitic carbon nitride as an electrode modifier to facilitate the electrochemical reaction, and thereby we can achieve higher sensitivity than the previously reported methods. Herein for the first time, we employed high energy ball milling method to prepare S-doped graphitic carbon nitride and then characterized it with various analytical methods to understand structural characteristics, electronic properties, and crystallinity.…”

Selective and Sensitive Electrochemical Detection of ATP in Human Serum Samples at ZrO2 Hallow Spheres Modified GCE

“…31 Recently, Kalaiyarasi and Pandian prepared an Al 2 O 3 hollow sphere based on the carbon sphere as a hard template and then successfully exploited it for electrochemical determination of MNZ in tablets and urine samples. 32 Jiaguo et al, have been reported as template free the hollow spheres in high yields by a facial hydrothermal reaction by using urea and potassium aluminium sulphate reaction mixtures. 33 Similar we can prepare various hollow spheres and metal oxides using the carbon sphere as a hard template for different applications.…”

Sonochemically Recovered Aluminum Oxide Nanoparticles from Domestic Aluminum Wastes as a Highly Stable Electrocatalyst for Proton-Pump Inhibitor (Omeprazole) Detection

“…[20][21][22][23][24][25][26][27] Recently the reported articles highlighted about electrochemical biosensing of living cell's cofactors, 28 organophosphate pesticides, 29 phenolic compounds, 30 and monitoring of microbial cell viability 31 using cost-effective 32 aluminum modifiers. [33][34][35][36][37] In this article, a novel method for the sensitive and selective detection of OMZ by direct reduction method was reported. Al 2 O 3 NPs were recovered through a simple sonochemical route and modified glassy carbon electrode was fabricated.…”