Egg Oral Immunotherapy (OIT) Induces Clinical Desensitization in a Double-Blind, Placebo-Controlled (DBPC) Trial in Egg Allergic Children from the Consortium of Food Allergy Research (CoFAR)

Jones, Stacie M.; Fleischer, David M.; Sicherer, Scott H.; Wood, Robert A.; Lindblad, Robert; Stablein, Donald M.; Liu, A.H.; Shreffler, Wayne G.; Leung, Donald Y.M.; Sampson, Hugh A.; Burks, A. Wesley

doi:10.1016/j.jaci.2010.01.011

Cited by 2 publications

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“…Although this study is currently ongoing, interim results were reported at the 2010 annual meeting of the American Academy of Allergy, Asthma and Immunology [25]. After 10 months of maintenance treatment with a maximum dose of 2 g of egg white powder per day, 21/40 (52.5%) of patients receiving egg OIT passed an oral food challenge and were considered desensitized, compared with zero of fifteen (0%) on placebo OIT; 30/40 (75%) had achieved desensitization after an additional year of therapy.…”

Section: Randomized Clinical Trialsmentioning

confidence: 98%

Egg oral immunotherapy

Vickery

2012

Current Opinion in Allergy &Amp; Clinical Immunology

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Egg OIT is a promising modality for providing temporary protection from reactions caused by accidental egg exposure. However, the overall strength of the evidence in favor of egg OIT is limited by small sample sizes and the lack of controls, both of which are important considerations given the spontaneous resolution expected in egg allergy. More high-quality studies are necessary before egg OIT can be recommended as a viable treatment option.

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Section: Randomized Clinical Trialsmentioning

confidence: 98%

Egg oral immunotherapy

Vickery

2012

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Although food immunotherapy studies have been focusing on treating patients with peanut or milk allergy, other studies have been done in wheat allergy [10], egg allergy, [11] or other less common allergens. Most food immunotherapy trials have been dealing with one food allergen only.…”

Section: Multiple Food Oitmentioning

confidence: 99%

Emerging Approaches to Food Desensitization in Children

Hamad

Burks

2017

Curr Allergy Asthma Rep

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Recent advancements in epicutaneous, sublingual, and oral immunotherapy for food allergy in the future may offer children with food allergy and their families a viable option to reduce risk or severity of anaphylaxis with phase III trials ongoing for two of these treatment modalities. Food allergy prevalence in children is estimated to be up to 8%. These children are at risk of significant allergic reactions and anaphylaxis. Food avoidance and use of antihistamines or epinephrine has been the standard of care for these patients. This approach also has a significant socioeconomic effects on patients and their families. Recent advancements in understanding food allergy have allowed for exploring new methods of treatment. There is an increasing interest in oral immunotherapy, epicutaneous immunotherapy, or sublingual immunotherapy for food allergy. There have been also innovative approaches to immunotherapy by modification of food allergens (to make them less allergenic while maintain their immunogenicity) or adding adjunctive treatments (probiotics, anti-IgE, etc.) to increase efficacy or safety.

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Egg Oral Immunotherapy (OIT) Induces Clinical Desensitization in a Double-Blind, Placebo-Controlled (DBPC) Trial in Egg Allergic Children from the Consortium of Food Allergy Research (CoFAR)

Cited by 2 publications

References 0 publications

Egg oral immunotherapy

Egg oral immunotherapy

Emerging Approaches to Food Desensitization in Children

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