EGFR Pathway-Based Gene Signatures of Druggable Gene Mutations in Melanoma, Breast, Lung, and Thyroid Cancers

Raevskiy, Mikhail; Sorokin, Maxim; Vladimirova, Uliana; Suntsova, Maria; Efimov, Victor; Garazha, Andrew; Drobyshev, Alexei L.; Moisseev, Aleksey; Румянцев, П. О.; Li, Xinmin; Buzdin, Anton

doi:10.1134/s0006297921110110

Cited by 4 publications

(4 citation statements)

References 47 publications

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“…6). Such expression pattern of ErbB-1 induces higher proliferative capacity, increased vessel density, cellular atypias, high mitotic activity, and distinctive infiltrative phenotype in both types of tissues, and these changes may bring forth their oncogenic potential [57,[60][61][62][63][64][65]. The observed cytoplasmic and nuclear distribution of ErbBs, especially for ErbB-1 and ErbB-3, besides their membranous localization in the eutopic endometrium during endometriosis may trigger pathogenic potential of eutopic endometrium [66][67][68][69][70].…”

Section: Discussionmentioning

confidence: 99%

Overexpression of ErbB-1 (EGFR) Protein in Eutopic Endome-Trium of Infertile Women with Severe Ovarian Endometriosis during the ‘Implantation Window’ of Menstrual Cycle

Poorasamy¹,

Garg²,

Bharti³

et al. 2022

Preprint

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Several lines of evidence indicate that high proliferative bias in eutopic endometrium during secretory phase is a hallmark of endometriosis and that high occurrence of implantation failure in patients resulting in infertility is often associated with endometriosis. ErbB family of proteins, which regulate the proliferation capacity in mammalian cells, appear as potential group of proteins to cause higher proliferation and endometrial hostility to implantation process in endometriosis. However, we have no concrete knowledge regarding the involvement of ErbB family in human endometrium during the ‘implantation window’, i.e., days 20-24 of a typical ovulatory cycle in endometriosis associated infertility. In the present study, the cellular profiles of immunopositive ErbBs-1 to -4 in endometrium of endometriosis-free, infertile women (Group 1; n=11), and in eutopic endometrium of infertile women diagnosed with stage IV ovarian endometriosis (Group 2; n=13) during mid-secretory phase were examined and compared using standardized WERF EPHect guidelines. Computer-aided standardized combinative analysis of immunoprecipitation in different compartments revealed an overexpression of ErbB-1 in the epithelial, stromal and vascular compartments along with marginally higher ErbB-3 expressions (P< 0.06) in the vascular compartment and ErbB-4 expression (P< 0.05) in the glandular epithelium and stroma in endometrium during the window of implantation of women with primary infertility associated with stage IV ovarian endometriosis compared with disease-free endometrium from women. A global overexpression of ErbB-1 in the endometrium during implantation window may induce anomalous proliferative, inflammatory and angiogenic activities in it, which antagonizes endometrial preparation for embryo implantation.

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Section: Discussionmentioning

confidence: 99%

Overexpression of ErbB-1 (EGFR) Protein in Eutopic Endome-Trium of Infertile Women with Severe Ovarian Endometriosis during the ‘Implantation Window’ of Menstrual Cycle

Poorasamy¹,

Garg²,

Bharti³

et al. 2022

Preprint

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“…39-41;Cohen 1994). Moreover, a panoply with Heraklean imagery would also have evoked narratives that reinforced the identity and legitimacy of its bearer in the eyes of its Scythian beholders, as Herakles famously sired their mythical eponym ancestor Skythes during his Pontic wanderings (Raevskiy 1977;Hinge 2008;Lincoln 2014). Entangling Scythian and Greek strands of Herakles'myths and imagery would also have reinforced the propriety of the Scythian/Ionian symbiosis, which was the basis of the success of Miletus' Pontic apokiai (Braund 2021).…”

Section: )mentioning

confidence: 99%

Violent Raiding, Systematic Slaving, and Sweeping Depopulation? Re-Evaluating the Scythian Impact on Central Europe through the Lens of the Witaszkowo/Vettersfelde Hoard

Nebelsick

2024

Arts

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In 1882, the lavishly decorated golden regalia of a steppe nomad warrior prince, which was crafted in the late sixth century BCE in a “bilingual” Scythian–Milesian workshop on the Black Sea coast, was found on the edge of a Lusatian swamp 120 km southeast of Berlin. Its discovery and the ongoing findings of steppe nomad armaments—arrows, battle axes, and swords—in central Europe have led to a lively debate about the nature of Scythian–Indigenous interaction in the Early Iron Age, ranging from benign visions of long-term acculturation to violent scenarios of short-term raiding. In this article, I argue that an analysis of the iconography of the Witaszkowo hoard and new information from excavations at its find spot make it likely that it was sent as a diplomatic gift by Scythian elites to an indigenous leader and deposited by the local community as a votive hoard. An affirmation of the compact chronological range of Scythian artefacts found in the west, growing evidence for the destruction of indigenous strongholds by horse-borne archers, and concurrent evidence for the drastic depopulation of vast landscapes in the second half of the sixth century BCE allow us to envisage the gifting of this hoard as an episode of a fierce and destructive altercation. It is posited that this onslaught was a facet of the western thrust of the Lydian and Persian Empires, and that its extirpative impact was the result of systematic, commercially driven slaving triggered by the concurrent monetisation of the economies of the Black Sea coast. The effects of these raids on Eastern Central Europe’s later prehistoric communities are made manifest by analogies to the disastrous ramifications of the transatlantic slave trade on societies of 16th-to-18th-century West Africa.

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“…The study group reported differences between FTCs and PTCs regarding the rates of these pointmutations, but they also concluded that their accumulation is responsible for aggressive phenotypes (increased dedifferentiation). Furthermore, EGFR/BRAF/PIK3CA/m TOR/KRAS pathway is frequently altered in malignancies including thyroid carcinoma, according to an RNA sequencing CANCER DIAGNOSIS & PROGNOSIS 3: 151-156 (2023) profile analysis (23). The study group proposed that overexpression of the markers -due to activating point mutationsleads to aberrant transcriptomic activity in these malignancies.…”

Section: Egfr Alterations In Thyroid Carcinomamentioning

confidence: 99%

Anti-EGFR/BRAF-Tyrosine Kinase Inhibitors in Thyroid Carcinoma

Papanikolaou¹,

Kyrodimos²,

Mastronikolis³

et al. 2023

CDP

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Alterations in significant genes located on chromosome 7 - including epidermal growth factor receptor (EGFR) and also v-Raf murine sarcoma viral oncogene homolog B (BRAF) as a mitogen-activated protein kinase (MAPK) - combined or not with numerical imbalances of the whole chromosome (aneuploidy-polysomy) are crucial genetic events involved in the development and progression of malignancies. Identification of EGFR/BRAF-dependent specific somatic mutations and other mechanisms of deregulation (i.e., amplification) is critical for applying targeted therapeutic approaches [tyrosine kinase inhibitors (TKIs] or monoclonal antibodies (mAbs). Thyroid carcinoma is a specific pathological entity characterized by a variety of histological sub-types. Follicular thyroid carcinoma (FTC), papillary thyroid carcinoma (PTC), medullary thyroid carcinoma (MTC), and anaplastic thyroid carcinoma (ATC) represent its main sub-types. In the current review, we explore the role of EGFR/BRAF alterations in thyroid carcinoma in conjunction with the corresponding anti-EGFR/BRAF TKI-based novel therapeutic strategies for patients with specific genetic signatures.

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EGFR Pathway-Based Gene Signatures of Druggable Gene Mutations in Melanoma, Breast, Lung, and Thyroid Cancers

Cited by 4 publications

References 47 publications

Overexpression of ErbB-1 (EGFR) Protein in Eutopic Endome-Trium of Infertile Women with Severe Ovarian Endometriosis during the ‘Implantation Window’ of Menstrual Cycle

Overexpression of ErbB-1 (EGFR) Protein in Eutopic Endome-Trium of Infertile Women with Severe Ovarian Endometriosis during the ‘Implantation Window’ of Menstrual Cycle

Violent Raiding, Systematic Slaving, and Sweeping Depopulation? Re-Evaluating the Scythian Impact on Central Europe through the Lens of the Witaszkowo/Vettersfelde Hoard

Anti-EGFR/BRAF-Tyrosine Kinase Inhibitors in Thyroid Carcinoma

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