EGFR mutation profile in Australian patients with non-small cell lung cancer

Abstract

Please cite this article as: Mead S et al., EGFR mutation profile in Australian patients with non-small cell lung cancer, Pathology,

Squamous cell carcinoma differentiation at progression as a resistance mechanism in metastatic non-small cell lung carcinoma harbouring a targetable mutation

“…1 Most patients with SCC will have a prior smoking history, whereas a subset of patients with ADC have minimal or no cigarette exposure and these adenocarcinomas are associated with mutations of EGFR (approximately 47% in Asia-Pacific NSCLC/ADC cohorts 4 and 15% in Western cohorts). 5 Adenosquamous carcinomas (ADSC) are rare NSCLCs (2e3% of lung cancers) which by definition include at least 10% of both ADC and SCC in resection specimens. 2 They may occur in nonsmokers and may harbour similar oncogenic driver mutations to lung ADC 2 but can be difficult to diagnose in small biopsy samples and sampling bias may lead to misclassification as either ADC or SCC.…”