EGFR and microvessel density in canine malignant mammary tumours

Carvalho, Maria Isabel; Guimarães, Maria João; Pires, Isabel; Prada, Justina; Silva-Carvalho, Ricardo; Lopes, Carlos; Queiroga, Felisbina L.

doi:10.1016/j.rvsc.2013.09.003

Cited by 45 publications

(47 citation statements)

References 54 publications

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“…Some authors reported a relationship between higher EGFR levels and increased tumour size or the histological tumour type . In dogs, EGFR expression was significantly associated with tumour size, necrosis, mitotic index and histological grade of malignancy …”

Section: Discussionmentioning

confidence: 99%

“…Some authors have shown the link between EGFR immunoexpression and high tumour aggressiveness in canine mammary tumours (CMT) but failed to demonstrate a statistically significant association with prognosis . A positive correlation between increased EGFR immunoexpression and angiogenesis in malignant tumours was also described . However, the role of this receptor as a prognostic indicator as well as its role in the very aggressive histological type, canine inflammatory mammary carcinoma (IMC) needs to be better elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Quantification of epidermal growth factor receptor (EGFR) in canine mammary tumours by ELISA assay: clinical and prognostic implications

Queiroga

Alenza

González-Gil

et al. 2015

Vet Comparative Oncology

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The involvement of epidermal growth factor receptor (EGFR) is well established in human breast cancer, however, in canine mammary tumours (CMT), including inflammatory mammary carcinomas (IMC), still needs to be clarified. Enzyme immune assay techniques were used for EGFR determinations in tumour tissue from 45 bitches with CMT and in normal mammary glands from eight control dogs. Higher tissue EGFR levels were found in CMT compared with controls (P < 0.05). In malignant CMT, tissue EGFR elevated concentrations were statistically significantly associated with tumour relapse and/or distant metastasis during follow-up and with reduced disease-free and overall survival times. The IMC cases had the highest tissue EGFR levels compared with other malignant non-IMC tumours (P < 0.001). The results support the hypothesis that EGFR levels influence prognosis in malignant CMT, suggesting that EGFR may represent a therapeutic target in cases of high histological aggressiveness and especially in cases of metastatic phenotype and poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantification of epidermal growth factor receptor (EGFR) in canine mammary tumours by ELISA assay: clinical and prognostic implications

Queiroga

Alenza

González-Gil

et al. 2015

Vet Comparative Oncology

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“…Furthermore, malignant tumors have significantly more new vessels and proliferating endothelial cells compared with benign tumors and normal mammary gland tissues [32]. We have shown previously that high microvessel density in canine mammary cancer was significantly correlated with tubule formation, with the histological grade of malignancy and with clinical stage [37]. …”

Section: Inflammatory Cells and Sustained Angiogenesismentioning

confidence: 99%

A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs

Carvalho

Silva-Carvalho

Pires

et al. 2016

BioMed Research International

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Infiltrating cells of the immune system are widely accepted to be generic constituents of tumor microenvironment. It has been well established that the development of mammary cancer, both in humans and in dogs, is associated with alterations in numbers and functions of immune cells at the sites of tumor progression. These tumor infiltrating immune cells seem to exhibit exclusive phenotypic and functional characteristics and mammary cancer cells can take advantage of signaling molecules released by them. Cancer related inflammation has an important role in mammary carcinogenesis, contributing to the acquisition of core hallmark capabilities that allow cancer cells to survive, proliferate, and disseminate. Indeed, recent studies in human breast cancer and in canine mammary tumors have identified a growing list of signaling molecules released by inflammatory cells that serve as effectors of their tumor-promoting actions. These include the COX-2, the tumor EGF, the angiogenic VEGF, other proangiogenic factors, and a large variety of chemokines and cytokines that amplify the inflammatory state. This review describes the intertwined signaling pathways shared by T-lymphocytic/macrophage infiltrates and important tissue biomarkers in both human and dog mammary carcinogenesis.

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“…In addition, HER-2 overexpression in MMT has been positively associated with nuclear pleomorphism, high histological grade and mitotic count (Dutra et al, 2004). A recent study indicates that HER-2 contributes to increase the angiogenesis in mammary carcinomas (Carvalho et al, 2013).…”

Section: Genetic Factorsmentioning

confidence: 99%

Canine Mammary Tumors: Risk Factors, Prognosis and Treatments

2016

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Mammary tumors are the most common neoplasm in the female dog, with a median age of appearance between 9 and 11 years. They may appear as single or multiple nodules, and posterior mammary glands are more frequently affected than anterior glands. Both benign and malignant tumors may occur in the dog, and according to histological criteria, approximately 50% of the tumors are malignant. Mammary gland tumors tend to be heterogeneous in their pathological characteristics and clinical behavior. Different hormones and growth factors play a key role in the development of this neoplasm, however, the mechanism by which they influence tumor growth and their possible prognostic value are still under study. Besides, new therapeutic options for each particular tumor type are being developed. The aim of this article is to review pathological, prognostic and therapeutic aspects of canine mammary neoplasms.

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EGFR and microvessel density in canine malignant mammary tumours

Cited by 45 publications

References 54 publications

Quantification of epidermal growth factor receptor (EGFR) in canine mammary tumours by ELISA assay: clinical and prognostic implications

Quantification of epidermal growth factor receptor (EGFR) in canine mammary tumours by ELISA assay: clinical and prognostic implications

A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs

Canine Mammary Tumors: Risk Factors, Prognosis and Treatments

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