EGFP-FMRP Granules Are Proto-Granules That Can Be Shunted to Stress Granules During a Stress Response

Denman, Robert B.

doi:10.1038/npre.2010.5442

Cited by 1 publication

(6 citation statements)

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“…To confirm that AdOx treatment truly resulted in decreased cellular methylation we conducted Western blotting [19, 27] and immunostaining studies [19] using two antibodies that detect subsets of asymmetrically dimethylated (aDMA) proteins (Figure 3). Both assays showed a dose-dependent decrease in asymmetrically dimethylated proteins.…”

Section: Asymmetrically Dimethylated Rna-binding Proteins Are Founmentioning

confidence: 99%

“…(b) The graph shows the fluorescence intensities in both panels as a function of time. The results were adapted from Dolzhanskaya et al [27, Figure 9] and Dolzhanskaya et al [20, Figure 7].…”

Section: Figurementioning

confidence: 99%

“…Similar results are observed in cultured cells. The effect of AdOx on cellular protein methylation and the dose-dependent decrease following AdOx treatment using these antibodies can be found in Dolzhanskaya et al [27, Figures 10 and 13], [20, Figures 8 and 11], and [19, Figure S1].…”

Section: Figurementioning

confidence: 99%

“…Similar results occur with PRMT7, which appears to be strictly cytoplasmic in the presence of arsenite. The results have been adapted from Dolzhanskaya et al [27, Figure 17].…”

Section: Figurementioning

confidence: 99%

“…The graph quantifies the granule sizes of the colocalized and non-colocalized granules. The results were adapted from Dolzhanskaya et al [27, Figure 14] and [20, Figure 12].…”

Section: Figurementioning

confidence: 99%

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Protein Methylation and Stress Granules: Posttranslational Remodeler or Innocent Bystander?

Xie

Denman²

2011

Molecular Biology International

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Stress granules contain a large number of post-translationally modified proteins, and studies have shown that these modifications serve as recruitment tags for specific proteins and even control the assembly and disassembly of the granules themselves. Work originating from our laboratory has focused on the role protein methylation plays in stress granule composition and function. We have demonstrated that both asymmetrically and symmetrically dimethylated proteins are core constituents of stress granules, and we have endeavored to understand when and how this occurs. Here we seek to integrate this data into a framework consisting of the currently known post-translational modifications affecting stress granules to produce a model of stress granule dynamics that, in turn, may serve as a benchmark for understanding and predicting how post-translational modifications regulate other granule types.

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Section: Asymmetrically Dimethylated Rna-binding Proteins Are Founmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

“…Similar results occur with PRMT7, which appears to be strictly cytoplasmic in the presence of arsenite. The results have been adapted from Dolzhanskaya et al [27, Figure 17].…”

Section: Figurementioning

confidence: 99%

“…The graph quantifies the granule sizes of the colocalized and non-colocalized granules. The results were adapted from Dolzhanskaya et al [27, Figure 14] and [20, Figure 12].…”

Section: Figurementioning

confidence: 99%

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