“…Reportedly, MMP-9 plays a significant role in breast cancer invasion and metastasis via degrading type IV collagen-rich extracelluar matrix (Chen et al, 2011) , and also be regulated by TGF-β1, epidermal growth factor (EGF), fibroblast growth factor (FGF), Nerve growth factor (NGF), vascular endothelial growth factor (VEGF), etc., which secreted by cancer cells and/or host cells in the tumor microenvironment (Chou et al, 2006;Belotti et al, 2008;Blair et al, 2011). Among those factors, TGF-β1 generated by autocrine and paracrine is high related to malignant tumor (Na et al, 2010).…”