2008
DOI: 10.1016/j.canlet.2007.11.026
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EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells

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Cited by 118 publications
(99 citation statements)
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“…Phosphorylation of AKT at Ser473 in SMMC7721 cells was reduced by EGCG (Fig. 5), which was consistent with a previous study of HepG2 cells, reporting that EGCG induced apoptosis and caused a decrease in the p-IGF-1R protein and its downstream signaling molecules including the p-ERK, p-Akt, p-Stat-3, and p-GSK-3β proteins (29).…”
Section: Discussionsupporting
confidence: 92%
“…Phosphorylation of AKT at Ser473 in SMMC7721 cells was reduced by EGCG (Fig. 5), which was consistent with a previous study of HepG2 cells, reporting that EGCG induced apoptosis and caused a decrease in the p-IGF-1R protein and its downstream signaling molecules including the p-ERK, p-Akt, p-Stat-3, and p-GSK-3β proteins (29).…”
Section: Discussionsupporting
confidence: 92%
“…Similar effects of GTCs have been observed towards IGF-R1 [74]. IGF-R1 is overexpressed in PCa [67].…”
Section: Cell Surface Receptorssupporting
confidence: 76%
“…These findings seem to be significant because the alteration of the IGF/ IGF-1R axis, which is induced by insulin resistance, is involved in liver carcinogenesis and thus might play a critical role as a molecular target for HCC chemoprevention (6)(7)(8). In human HCC-derived cells, IGF-1 and IGF-2 activate IGF-1R, ERK, and Akt proteins and increase the expression of IGF-1 and IGF-2 mRNAs themselves but EGCG inhibits these sequences and thus suppresses growth and induces apoptosis in HCC cells (13). These findings, together with the results of the present study, suggest the possibility that EGCG overcomes the stimulatory effects of IGFs, disrupts the IGF/IGF-1R-related autocrine/paracrine loops, and thereby prevents the development of obesityrelated liver tumorigenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Among such RTKs, the IGF-1R is one of the critical targets of EGCG with respect to its anticancer effects. In human HCC-and colon cancer-derived cells, EGCG suppresses cell growth by inhibiting the activation of the IGF/ IGF-1R axis and its downstream ERK (extracellular signalregulated kinase) and Akt proteins (13)(14)(15). EGCG also overcomes the activation of the IGF/IGF-1R axis and thereby inhibits the development of colonic premalignant lesions in an obesity-related colon carcinogenesis model (16).…”
Section: Introductionmentioning
confidence: 99%