EGCG/Gelatin-Doxorubicin Gold Nanoparticles Enhance Therapeutic efficacy of Doxorubicin for Prostate Cancer Treatment

Tsai, Li-Chu; Hsieh, Hao Ying; Lu, Kun Ying; Wang, Sin Yu; Mi, Fwu Long

doi:10.2217/nnm.15.183

Cited by 77 publications

(45 citation statements)

References 42 publications

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“…EGCG and gelatin-doxorubicin conjugate (GLT-DOX)-coated gold nanoparticles (DOX-GLT/EGCG AuNPs) were produced to improve specific uptake of doxorubicin in PC3 cells using EGCG/67-LR receptor-mediated delivery. Apoptosis of DOX-GLT/EGCG AuNPs treated PC3 was improved in comparison with cells treated with DOX [165].…”

Section: Nanotechnology Strategies To Improve Gtcs Bioactivitymentioning

confidence: 89%

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Naponelli¹,

Ramazzina²,

Lenzi³

et al. 2017

Preprint

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Green Tea Catechins (GTCs) are a family of chemically related compounds usually classified as antioxidant molecules. Epidemiological evidences, supported by interventional studies, highlighted a more than promising role for GTCs in human Prostate Cancer (PCa) chemoprevention.In the last decades many efforts have been made to gain new insights into the mechanism of action of GTCs. Now it is clear that GTCs anticancer action can no longer be simplistically limited to their direct antioxidant/pro-oxidant properties. Recent contributions to the advancement of knowledge in this field have shown that GTCs specifically interact with cellular targets including, cell surface receptors, lipid rafts and endoplasmic reticulum, modulate gene expression through direct effect on transcription factors or indirect epigenetic mechanisms, interfere with intracellular proteostasis at various levels. Many of the effects observed in vitro are dose and cell context dependent and take place at concentration that cannot be achieved in vivo.Poor intestinal absorption together with an extensive systemic and enteric metabolism influence GTCs bioavailability through still poor understood mechanisms. Recent efforts to develop delivery systems that increase GTCs overall bioavailability, by mean of biopolymeric nanoparticles, represent the main way to translate preclinical results in a real clinical scenario for PCa chemoprevention.

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Section: Nanotechnology Strategies To Improve Gtcs Bioactivitymentioning

confidence: 89%

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Naponelli¹,

Ramazzina²,

Lenzi³

et al. 2017

Preprint

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“…In addition, because DOX has the fluorophore feature, it is easily detected and quantitated; therefore, it has been extensively applied in many studies of tumor treatment using drug carriers, such as gold particles, magnetic particles, and microbubbles. 15,16 Some researchers have reported that pure low-frequency US could promote the uptake and distribution of liposomal DOX in prostate cancer xenografts, which might be associated with the production of cavitation nuclei by fluid in xenografts, such as blood under US excitation. 17 Since Gramiak et al first discovered that microbubbles could enhance US images in 1968, UCAs have received extensive attention.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of prostate cancer growth using doxorubicin assisted by ultrasound-targeted nanobubble destruction

Fan¹,

Wang²,

Guo³

et al. 2016

IJN

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Ultrasound (US)-targeted microbubble destruction has been widely used as an effective drug-delivery system. However, nanobubbles (NBs) have better stability and stronger penetration than microbubbles, and drug delivery assisted by US-targeted NB destruction (UTND) still needs to be investigated. Our aim was to investigate the effect of doxorubicin (DOX) on the inhibition of prostate cancer growth under UTND. Contrast-enhanced US imaging of transplanted PC3 prostate cancer in mice showed that under a combination of 1 W/cm 2 US power and a 100 Hz intermittent pulse with a “5 seconds on, 5 seconds off” mode, NBs with an average size of (485.7±33) nm were effectively destroyed within 15 minutes in the tumor location. PC3 cells and 20 tumor-bearing mice were divided into four groups: a DOX group, a DOX + NB group, a DOX + US group, and a DOX + NB + US group. The cell growth-inhibition rate and DOX concentration of xenografts in the DOX + NB + US group were highest. Based on another control group and these four groups, another 25 tumor-bearing mice were used to observe the treatment effect of nine DOX injections under UTND. The xenografts in the DOX + NB + US group decreased more obviously and had more cellular apoptosis than other groups. Finally, electron microscopy was used to estimate the cavitation effect of NBs under US irradiation in the control group, NB group, US group, and NB + US group. The results of scanning electron microscopy showed that PC3 cells in the DOX + NB + US group had more holes and significantly increased cell-surface folds. Meanwhile, transmission electric microscopy confirmed that more lanthanum nitrate particles entered the parenchymal cells in xenografts in the NB + US group compared with the other groups. This study suggested that UTND technology could be an effective method to promote drugs to function in US-irradiated sites, and the underlying mechanism may be associated with a cavitation effect.

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“…Additionally, gold nanoparticles (AuNPs) have attracted much attention in the field of biomedical imaging and clinical diagnostics, in the last decade [45,46]. These NPs can also be surface modified by attaching targeting ligands and tagged with imaging molecules for specificity and effectiveness of the cancer diagnosis and therapeutics [39].…”

Section: Cytotoxic Assay Pc3 Cellsmentioning

confidence: 99%

Characterization and Antitumor Activity of Chitosan/Poly (Vinyl Alcohol) Blend Doped with Gold and Silver Nanoparticles in Treatment of Prostatic Cancer Model

Abaza¹,

Mahmoud²,

Elsheikh³

2018

JPP

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Abstract:The application of nanotechnology in various fields of science has earned a great concern over the past decades. The natural products and surface-modified polymers and metallic nanoparticles (NPs) have evolved as promising nanomaterials for targeted prostate cancer treatment. In the present study, Chitosan/poly (vinyl alcohol) (Cs/PVA) blend was synthesized by gamma radiation which could behave a nanoreactor for silver (Ag) and gold (Au) nanoparticle with promising anticancer applications. (Cs/PVA/Ag) and (Cs/PVA/Au) nanocomposites were confirmed by SEM (scanning electron microscope) and TEM (transmission electron microscope) analysis. The swelling properties have been investigated as a function of time and pH. The anti-cancer activity of the prepared nanocomposites was demonstrated in prostatic cancer cell line. It has a significant effect against prostatic cancer. However, metal nanoparticles have shown a good experimental success in the field of nanomedicine especially in cancer treatment, which has always been an area of high concern. The collaboration of biomedical research in the identification and characterization of biomedical strategies using the interesting metal nanocomposite will impact the future nanomedicine greatly.

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EGCG/Gelatin-Doxorubicin Gold Nanoparticles Enhance Therapeutic efficacy of Doxorubicin for Prostate Cancer Treatment

Abstract: Laminin 67R receptor-mediated delivery of DOX using the AuNPs enhanced cellular uptake of DOX and improved apoptosis of PC-3 cells.

Cited by 77 publications

References 42 publications

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges

Inhibition of prostate cancer growth using doxorubicin assisted by ultrasound-targeted nanobubble destruction

Characterization and Antitumor Activity of Chitosan/Poly (Vinyl Alcohol) Blend Doped with Gold and Silver Nanoparticles in Treatment of Prostatic Cancer Model

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