eg occupancy as an effective descriptor for the catalytic activity of perovskite oxide-based peroxidase mimics

Wang, Xiaoyu; Gao, Xuejiao J.; Li, Qin; Wang, Changda; Li, Song; Zhou, Yong‐Ning; Zhu, Guoyin; Cao, Wenwu; Lin, Shichao; Zhou, Liqi; Wang, Kang; Zhang, Huigang; Jin, Zhong; Wang, Peng; Gao, Xingfa; Wei, Hui

doi:10.1038/s41467-019-08657-5

Cited by 242 publications

(192 citation statements)

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“…(1). In addition, Xiaoyu Wang et al 56 showed recently that the population of e g orbitals plays a fundamental role in the peroxidase-like catalytic activity of perovskite oxide-based nanosystems.…”

Section: Discussionmentioning

confidence: 99%

Free-Radical Formation by the Peroxidase-Like Catalytic Activity of MFe₂O₄ (M = Fe, Ni, and Mn) Nanoparticles

et al. 2019

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Ferrite Magnetic Nanoparticles (MNPs) have peroxidase-like activity and thus catalyze the decomposition of H 2 O 2 producing reactive oxygen species (ROS). Increasingly important applications of these Ferrite MNPs in biology and medicine require that their morphological, physicochemical and magnetic properties need to be strictly controlled. Usually, the tuning of their magnetic properties is achieved by the replacement of the Fe by other 3d metals, such as Mn or Ni. Here, we studied the catalytic activity for ferrite MNPs (MFe 2 O 4 , M = Fe 2+ /Fe 3+ , Ni, Mn) with mean diameter ranging from 10 to 12 nm. Peroxidase-like activity was studied by Electron Paramagnetic Resonance (EPR) using the spin-trap DMPO at different pHs (4.8, 7.4) and temperatures (25°C, 40°C). We identified an enhanced amount of the hydroxyl (•OH) and perhydroxyl (•OOH) radicals for all samples, compared to a blank solution. Quantitative studies show that [•OH] is the dominant radical formed for Fe 3 O 4 , which is strongly reduced with the concomitant oxidation of Fe 2+ or its substitution (Ni or Mn). A comparative analysis of the EPR data against in vitro production of ROS in microglial BV2 cell culture provided additional insight regarding the catalytic activity of ferrite MNPs, which should be considered if biomedical uses are intended. Our results contribute to a better understanding of the role played by different divalent ions in the catalytic activity of Ferrite nanoparticles, which is very important concerning their use in biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Free-Radical Formation by the Peroxidase-Like Catalytic Activity of MFe₂O₄ (M = Fe, Ni, and Mn) Nanoparticles

et al. 2019

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“…Gold nanoparticles (AuNPs) exhibit GOX‐like activity that can decompose glucose into gluconic acid and H 2 O 2 (Luo et al., ). Recent studies revealed that the multiple nanozyme activities are a possible consequence of a huge collection of active nanostructures, which precisely manipulate the distribution and arrangements of different atoms inside to mediate redox cycles and electron‐transfer communications during catalysis (Wang, Guo et al., ).…”

Section: Principles Of Detection Using Enzyme‐mimetic Nanomaterialsmentioning

confidence: 99%

Development of Nanozymes for Food Quality and Safety Detection: Principles and Recent Applications

Huang

Sun

et al. 2019

Comp Rev Food Sci Food Safe

139

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The public concerns about agrifood safety call for innovative and reformative analytical techniques to meet the inspection requirements of high sensitivity, specificity, and reproducibility. Enzyme‐mimetic nanomaterials or nanozymes, which combine enzyme‐like properties with nanoscale features, emerge as an excellent tool for quality and safety detection in the agrifood sector, due to not only their robust capacity in detection but also their attraction in future‐oriented exploitations. However, in‐depth understanding about the fundamental principles of nanozymes for food quality and safety detection remains limited, which makes their applications largely empirical. This review provides a comprehensive overview of the principles, designs, and applications of nanozyme‐based detection technique in the agrifood industry. The discussion mainly involves three mimicking types, that is, peroxidase, oxidase, and catalase‐like nanozymes, capable of detecting major agrifood analytes. The current principles and strategies are classified and then discussed in details through discriminating the roles of nanozymes in diverse detection platforms. Thereafter, recent applications of nanozymes in detecting various endogenous ingredients and exogenous contaminants in foods are reviewed, and the outlook of profound developments are explained. Evidenced by the increasing publications, nanozyme‐based detection techniques are narrowing the gap to practical‐oriented food analytical methods, while some challenges in optimization of nanozymes, diversification of recognition‐to‐signal manners, and sustainability of methodology need to conquer in the future.

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“…Regarding the efficiency of such as catalysis, Wang et al recently showed that e g orbital (d x2-y2 and d z2 ) occupancy could be an excellent measure of peroxidase like activity of transition metal oxide nanozymes 44 . Their study established a volcano relationship of activity with the average e g occupancy on a salce of 0--2.…”

Section: Main Textmentioning

confidence: 99%

Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington’s Like Disorder in Preclinical Model

Adhikari

Mondal

Das

et al. 2020

Preprint

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The potentiality of nano-enzymes in therapeutic use has directed contemporary research to develop a substitute for natural enzymes, which are suffering from several disadvantages including low stability, high cost, and difficulty in storage. However, inherent toxicity, inefficiency in the physiological milieu, and incompatibility to function in cellular enzyme networks limit the therapeutic use of nanozymes in living systems. Here, we have shown that citrate functionalized manganese-based biocompatible nanoscale material (C-Mn3O4 NP) efficiently mimics glutathione peroxidase enzyme in the physiological milieu and easily incorporates into the cellular multienzyme cascade for H2O2 scavenging. A detailed computational study reveals the mechanism of the nanozyme action. We further established the in vivo therapeutic efficacy of C-Mn3O4 nanozyme in a preclinical animal model of Huntington’s disease, a prevalent progressive neurodegenerative disorder, which has no effective medication till date.SUMMARYAlthough, nano-enzymes have shown lots of promises in the management of several diseases, two major concerns limit their clinical translation. Apart from the inherent toxicity of the constituent materials (e.g., cerium, vanadium, gold, etc.), activities of contemporary nanozymes are often inhibited in physiological milieu. Furthermore, most of them are incapable of incorporation into the cellular metabolic networks for functioning in tandem and parallel with natural enzymes, a major criteria for potential therapeutics.Here, we have shown that citrate-functionalized spherical Mn3O4 nanoparticles can efficiently mimic glutathione peroxidase (GPX) enzyme without the limitations of contemporary nanozymes, and effectively manage neurodegenerative Huntington’s disease in preclinical animal model. The choice of the material in the nanozyme lies on the fact that Mn is an essential micronutrient for mammals, and the stabilizing ligand citrate helps the nanoparticles to cross the blood-brain-barrier to reach brain. We have shown that the nanozyme can easily be incorporated in cellular antioxidant enzyme cascade. The specificity and efficacy of the nanozyme in the cascade was significantly higher compared to other reported nanozymes. We have justified our experimental findings with a detailed computational study. Understanding the mode of operation and management of Huntington’s disease in preclinical animal trial using a biocompatible (non-toxic) nanozyme as a part of the metabolic network may uncover a new paradigm in nanozyme based therapeutic strategy.

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eg occupancy as an effective descriptor for the catalytic activity of perovskite oxide-based peroxidase mimics

Cited by 242 publications

References 50 publications

Free-Radical Formation by the Peroxidase-Like Catalytic Activity of MFe₂O₄ (M = Fe, Ni, and Mn) Nanoparticles

Free-Radical Formation by the Peroxidase-Like Catalytic Activity of MFe₂O₄ (M = Fe, Ni, and Mn) Nanoparticles

Development of Nanozymes for Food Quality and Safety Detection: Principles and Recent Applications

Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington’s Like Disorder in Preclinical Model

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eg occupancy as an effective descriptor for the catalytic activity of perovskite oxide-based peroxidase mimics

Cited by 242 publications

References 50 publications

Free-Radical Formation by the Peroxidase-Like Catalytic Activity of MFe2O4 (M = Fe, Ni, and Mn) Nanoparticles

Free-Radical Formation by the Peroxidase-Like Catalytic Activity of MFe2O4 (M = Fe, Ni, and Mn) Nanoparticles

Development of Nanozymes for Food Quality and Safety Detection: Principles and Recent Applications

Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington’s Like Disorder in Preclinical Model

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Product

Resources

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Free-Radical Formation by the Peroxidase-Like Catalytic Activity of MFe₂O₄ (M = Fe, Ni, and Mn) Nanoparticles

Free-Radical Formation by the Peroxidase-Like Catalytic Activity of MFe₂O₄ (M = Fe, Ni, and Mn) Nanoparticles