“…Firstly, the transduction phase is given by the conversion of the painful stimulus to an action potential that is mediated by the response of in ammatory factors; then occurs the transmission phase where the action potential propagates from the periphery to the somatosensory cortex; thirdly, in the modulation phase, two processes occur: sensitization, which corresponds to the neurochemical activation that favors the capacity to respond to stimuli, and inhibition, which can be opioid, non-opioid and segmental, also known as pain gating. Finally, the last phase consists of perception where the stimulus that reaches the cortex connects with the limbic area and frontal cortex triggering the individual's response and assimilation to pain [12,13]. Some factors have been associated with poor control of acute APP, thus, in 2019, a systematic review and meta-analysis identi ed nine factors statistically signi cant and supported by greater evidence, such as female sex, smoking, history of depressive and anxious symptoms, sleep disorders, high body mass index, presence of preoperative pain, use of preoperative analgesia and young age [14], mainly in under 30 year old patients with a greater tendency to report APP [5].…”