Eficacia del tratamiento nutricional primario en la enfermedad de Crohn pediátrica

López, Víctor Manuel Navas; Alonso, J. Blasco; Salinas, C. Sierra; Gálvez, Ana; Recio, M.I. Vicioso

doi:10.1016/s1695-4033(08)75232-9

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…Both oral and enteral nutrition with TGF-β significantly mitigated IBD symptoms as well as lessened the severity of disease symptoms ( 125–127 ). An example of the above beneficial effects might be clinical remission and diminished inflammation observed ( 126 ) in a study in which children received a TGF-β–enriched mixture for 8 wk. In another study, administration of TGF-β2 in the oral polymeric diet, called CT3211, has been correlated with a clinical remission rate in 79% of the pediatric CD patients ( 128 ).…”

Section: The Role Of Bc Constituents In Ibdmentioning

confidence: 99%

Supplementation of Bovine Colostrum in Inflammatory Bowel Disease: Benefits and Contraindications

Sienkiewicz

Szymańska

Fichna

2021

Advances in Nutrition

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Inflammatory bowel disease (IBD) is a group of chronic relapsing disorders whose etiology has not been fully explained. Therefore, available therapeutic approaches for IBD patients are still insufficient. Current treatment strategies are targeted to immune system dysfunctions, often associated with alternations in the microbiota, which contribute to the development of chronic intestinal inflammation. Therapeutics include anti-inflammatory drugs such as aminosalicylates and corticosteroids, immunosuppressive agents, antibiotics, and biological agents such as infliximab and vedolizumab. Auxiliary therapies involve a balanced and personalized diet, healthy lifestyle, avoiding stress, as well as dietary supplements. In this review, we discuss the use of bovine colostrum (BC) as a therapeutic agent, including its advantages and contraindications. We summarize our knowledge on well-researched BC constituents and their effects on the gastrointestinal tract as evidenced in in vitro and in vivo studies.

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Section: The Role Of Bc Constituents In Ibdmentioning

confidence: 99%

Supplementation of Bovine Colostrum in Inflammatory Bowel Disease: Benefits and Contraindications

Sienkiewicz

Szymańska

Fichna

2021

Advances in Nutrition

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“…In mouse models of intestinal inflammation, dietary TGF-β supplementation was associated with improvements in inflammatory pathology and weight retention [213]. Following several successful clinical trials [214,215] TGF- β supplemented formula is now widely used to treat pediatric Crohn’s disease.…”

Section: Postnatal Acquisition Of the Gut Microbiome And Education Ofmentioning

confidence: 99%

Morphogenesis and maturation of the embryonic and postnatal intestine

Chin

Hill

Aurora

et al. 2017

Seminars in Cell & Developmental Biology

166

129

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The intestine is a vital organ responsible for nutrient absorption, bile and waste excretion, and a major site of host immunity. In order to keep up with daily demands, the intestine has evolved a mechanism to expand the absorptive surface area by undergoing a morphogenetic process to generate finger-like units called villi. These villi house specialized cell types critical for both absorbing nutrients from food, and for protecting the host from commensal and pathogenic microbes present in the adult gut. In this review, we will discuss mechanisms that coordinate intestinal development, growth, and maturation of the small intestine, starting from the formation of the early gut tube, through villus morphogenesis and into early postnatal life when the intestine must adapt to the acquisition of nutrients through food intake, and to interactions with microbes.

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“…Administration of primary nutritional therapy with exclusive enteral formula feeds (polymeric semi-elemental, or elemental formula) for eight weeks induces clinical remission and reduces inflammatory activity in the intestinal mucosa [37]. Dietary therapy has also been used in other inflammatory bowel conditions except IBD.…”

Section: Fecal Calprotectinmentioning

confidence: 99%

The Role of Calprotectin in Pediatric Disease

Vaos

Kostakis

Zavras

et al. 2013

BioMed Research International

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Calprotectin (CP) is a calcium- and zinc-binding protein of the S100 family expressed mainly by neutrophils with important extracellular activity. The aim of the current review is to summarize the latest findings concerning the role of CP in a diverse range of inflammatory and noninflammatory conditions among children. Increasing evidence suggests the implication of CP in the diagnosis, followup, assessment of relapses, and response to treatment in pediatric pathological conditions, such as inflammatory bowel disease, necrotizing enterocolitis, celiac disease, intestinal cystic fibrosis, acute appendicitis, juvenile idiopathic arthritis, Kawasaki disease, polymyositis-dermatomyositis, glomerulonephritis, IgA nephropathy, malaria, HIV infection, hyperzincemia and hypercalprotectinemia, and cancer. Further studies are required to provide insights into the actual role of CP in these pathological processes in pediatrics.

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Eficacia del tratamiento nutricional primario en la enfermedad de Crohn pediátrica

Cited by 7 publications

References 36 publications

Supplementation of Bovine Colostrum in Inflammatory Bowel Disease: Benefits and Contraindications

Supplementation of Bovine Colostrum in Inflammatory Bowel Disease: Benefits and Contraindications

Morphogenesis and maturation of the embryonic and postnatal intestine

The Role of Calprotectin in Pediatric Disease

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