Eficacia de lanreótido en pacientes con angiodisplasias gastrointestinales refractarias al tratamiento con octreótido

Ramos-Rosario, Huascar Alexis; Aranda, Ester Badia; Lorente, José Luis Martín; García, Lara Arias; Sicilia, Beatriz; Sáez-Royuela, F

doi:10.1016/j.gastrohep.2015.02.008

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…These results are in line with previous observational data indicating a decrease in bleeding and pRBC transfusion requirements in patients treated with octreotide, octreotide-LAR or lanreotide. 24 – 43 The quantity of effect observed in the ANGIOPAS study was in the range of these cases and in particular, of three series with significant transfusion requirements. 39 , 40 , 43 …”

Section: Discussionmentioning

confidence: 95%

“…Several observational studies and a meta-analysis consistently suggested that somatostatin analogs could reduce rebleeding and transfusion requirements in patients with GIADs bleeding refractory or inaccessible to endoscopic therapies 24 – 44 ( Table 1 ). However, the studies testing various therapeutic schedules used an inadequate design and failed to demonstrate this putative benefit.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and safety of pasireotide-LAR for the treatment of refractory bleeding due to gastrointestinal angiodysplasias: results of the ANGIOPAS multicenter phase II noncomparative prospective double-blinded randomized study

Bénamouzig¹,

Benallaoua

Saurin

et al. 2018

Therap Adv Gastroenterol

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Background:Gastrointestinal angiodysplasias (GIADs) could be responsible for recurrent bleeding and severe anemia. Somatostatin analogs could reduce transfusion requirements in these patients but no randomized controlled study is available. The main objective of the ANGIOPAS phase II double-blinded randomized, noncomparative study was to assess the effectiveness of pasireotide-LAR in reducing transfusion requirements in patients with refractory GIADs bleeding.Methods:A total of 22 patients with transfusion requirements ⩾6 units of packed red blood cells (pRBCs) during the 6 months prior to inclusion were randomized to receive pasireotide-LAR 60 mg (n = 10) or placebo (n = 12) every 28 days for 6 months. Patients were then followed for an additional 6 months after stopping treatment.Results:The pasireotide-LAR and placebo groups were equivalent for age, sex, comorbidities and transfusion requirement during the reference period (median 13 and 9.5 pRBCs). A 50 and 83% success rate (success defined as a decrease of at least 30% of transfused pRBCs) was observed in the pasireotide-LAR arm in the Intent to Treat (ITT) and per protocol (PP) analysis respectively. The need for transfusion during the intervention period was 3 pRBC units in the pasireotide-LAR group (range 0–26) and 11.5 pRBC units in the placebo group (range 0–23). Overall, three cases with glycemic control impairment were observed in the pasireotide-LAR group including one de novo diabetes.Conclusion:This double-blinded noncomparative randomized phase II study suggests, for the first time, the effectiveness of pasireotide-LAR 60 mg every 28 days to decrease the transfusion requirement in patients with recurrent bleeding due to GIADs.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of pasireotide-LAR for the treatment of refractory bleeding due to gastrointestinal angiodysplasias: results of the ANGIOPAS multicenter phase II noncomparative prospective double-blinded randomized study

Bénamouzig¹,

Benallaoua

Saurin

et al. 2018

Therap Adv Gastroenterol

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“…La principal limitación de estos estudios es la pequeña muestra poblacional (debida a la baja prevalencia de la enfermedad) como también exponen Ramos-Rosario et al (2016), Molina et al (2007) y Scaglione et al (2007). Entendemos que ello se corrige en parte en nuestro estudio, si bien persiste la gran heterogeneidad de pacientes, con elevadas comorbilidades, múltiples localizaciones y edad avanzada (Molina et al, 2012).…”

Section: Discussionunclassified

“…La malformación vascular más común del tracto digestivo son las angiodisplasias gastrointestinales (GIADs) (Ramos-Rosario et al, 2016). Se caracterizan por una dilatación venocapilar (Arribas et al, 2017;Jackson et al, 2017), con elevada fragilidad vascular.…”

Section: Introductionunclassified

Uso de análogos de somatostatina en las angiodisplasias gastrointestinales refractarias a otros tratamientos

et al. 2019

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La malformación vascular más común del tracto digestivo son las angiodisplasias gastrointestinales. Se caracterizan por una dilatación venocapilar con elevada fragilidad vascular, estado patológico que deriva en sangrados gastrointestinales. La prevalencia aumenta en pacientes de edad avanzada y pluripatológicos, lo que condiciona el tratamiento y pronóstico de las angiodisplasias.El objetivo es evaluar la eficacia del tratamiento de las angiodisplasias con análogos de somatostatina, siendo estos el Octreótido y el Lanreótido (fuera de ficha técnica para la indicación), en condiciones de práctica clínica habitual. Además, se tratará de relacionar la respuesta terapéutica con la localización de las lesiones, comorbilidades, reingresos, transfusiones sanguíneas y prescripción de anticoagulantes.Se llevó a cabo un estudio observacional retrospectivo con datos obtenidos de pacientes tratados en el Complejo Asistencial Universitario de León. Tras el análisis estadístico de los datos, se concluyó que no existen diferencias significativas entre los fármacos. Tampoco se encontró asociación significativa del éxito con las localizaciones de las angiodisplasias, ni con las comorbilidades coexistentes, ni con la toma de anticoagulantes. Sólo tratamientos de larga duración (> 11 meses) se relacionan con indicadores objetivos de éxito, como la reducción del número de transfusiones y de reingresos.

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Lanreotide in the management of small bowel angioectasias: seven-year data from a tertiary centre

Zammit

Sanders

Sidhu

2017

Scandinavian Journal of Gastroenterology

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Eficacia de lanreótido en pacientes con angiodisplasias gastrointestinales refractarias al tratamiento con octreótido

Cited by 5 publications

References 6 publications

Efficacy and safety of pasireotide-LAR for the treatment of refractory bleeding due to gastrointestinal angiodysplasias: results of the ANGIOPAS multicenter phase II noncomparative prospective double-blinded randomized study

Efficacy and safety of pasireotide-LAR for the treatment of refractory bleeding due to gastrointestinal angiodysplasias: results of the ANGIOPAS multicenter phase II noncomparative prospective double-blinded randomized study

Uso de análogos de somatostatina en las angiodisplasias gastrointestinales refractarias a otros tratamientos

Lanreotide in the management of small bowel angioectasias: seven-year data from a tertiary centre

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