Efforts to eliminate schistosomiasis in Hubei province, China: 2005–2018

Zhu, Hong; Li, Jianbing; Xiao, Ying; Tu, Zu-Wu; Xiao-Wei, Shan; Li, Bo; Wu, Jiali; Zhou, X. R.; Sun, Lingcong; Xia, Jianghai; Liu, Si; Huang, Xi-Bao

doi:10.1016/j.actatropica.2022.106417

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…Although a number of prevention and control measures have been taken to prevent the spread of schistosomiasis in foci, the transmission rate of schistosomiasis in Hubei Province still ranks the first due to its largest area of fresh water. 4 Hepatic schistosomiasis is the most typical form of schistosomiasis. After penetrating the skin, worms migrate to the mesenteric vein to parasitize, mate and lay eggs.…”

Section: Introductionmentioning

confidence: 99%

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High level of C3 is associated with Th2 immune response and liver fibrosis in patients with schistosomiasis

Wang,

Gong,

Nie

et al. 2024

Parasite Immunology

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Long‐term infection of schistosomiasis will seriously affect the liver health of patients. The serum of 334 chronic Schistosoma japonicum patients and 149 healthy volunteers was collected. Compared with heathy people, the level of C4 (complement 4) was increased, and the level of C3 (complement 3) was in an obvious skewed distribution. ELISA was performed to detect the serum cytokines, the results showed that the levels of IFN‐γ (interferon‐γ), IL (interleukin)‐2 and TNF‐α (tumour necrosis factor‐α) were reduced, while the levels of Th2 cytokines (IL‐4, IL‐6 and IL‐10) were increased. In the serum of patients with high C3, the secretion of HA (hyaluronic acid), LN (laminin), IV‐C (type IV collagen) and PCIII (type III procollagen) were increased, the activation of hepatic stellate cells was promoted. Exogenous human recombinant C3 made mice liver structure of the mice damaged and collagen deposition. IFN‐γ and IFN‐γ/IL‐4 were decreased, while HA, LN, PCIII and IV‐C were increased, and the expressions of α‐SMA and TGF‐β1 in liver tissues were up‐regulated. However, the addition of IFN‐γ partially reversed the effect of C3 on promoting fibrosis. High level of C3 is associated with Th2 immune response and liver fibrosis in patients with schistosomiasis.

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Section: Introductionmentioning

confidence: 99%

“…Hubei Province is one of the most severely affected areas of schistosomiasis in China. Although a number of prevention and control measures have been taken to prevent the spread of schistosomiasis in foci, the transmission rate of schistosomiasis in Hubei Province still ranks the first due to its largest area of fresh water 4 …”

Section: Introductionmentioning

confidence: 99%

High level of C3 is associated with Th2 immune response and liver fibrosis in patients with schistosomiasis

Wang,

Gong,

Nie

et al. 2024

Parasite Immunology

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“…However, a total of 53,254 existing habitats for the vector were identified, with three clusters in the Sichuan Basin, Dongting Lake, and Poyang Lake. These snail habitats are spread across 12 provinces covering an area of 3.58 billion m 2 , where Oncomelania hupensis (O. hupensis) was identified through a nationwide survey in 2016 (4). Schistosomiasis can be acquired after exposure to freshwater cercariae released from O. hupensis (5).…”

Section: Introductionmentioning

confidence: 99%

“…Schistosomiasis, caused by Schistosoma japonicum (S. japonicum) , was highly prevalent in China before the initiation of the national schistosomiasis control program in the mid-1950s ( 1 ). The symptoms of schistosomiasis include abdominal pain, diarrhea, bloody stools, fever, enlarged spleen or liver, liver fibrosis, portal hypertension, and fluid accumulation in the peritoneal cavity ( 2 ). Remarkable progress in schistosomiasis control has been achieved in China since the launch of the national program.…”

Section: Introductionmentioning

confidence: 99%

Protection motivation theory in predicting intentional behaviors regards schistosomiasis: a WeChat-based qualitative study

Wang,

Li,

Zhang

et al. 2024

Front. Public Health

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BackgroundModifications of behavior can help reduce the risk of transmission by disrupting the parasite life cycle. Behavior intension is a necessary intermediate step in behavior change. This study aimed to explore protection motivation theory (PMT) in predicting likelihood of engagement in protective behavior against infection with Schistosoma.MethodsIn China, a questionnaire for data collection was sent to users who followed the WeChat public account from June 2 to 6, 2023. Factors affecting intentional behavior of participants were analyzed using stepwise regression analysis and structural equation modeling.ResultsA total of 2,243 valid questionnaires were collected, with a mean age of 30 ± 8.4 years. Approximately 1,395 (62.2%) participants reported that they had been exposed to wild waters in daily work and life. About 51.0 and 50.7% of respondents reported never having been exposed to wild water in the last 3 and 6 months, respectively. Results indicated that prior knowledge of schistosomiasis was associated with the 7 PMT subconstructs, which then influenced future preventative behaviors.ConclusionBehavior intentionis a complicated and indispensable part of behavior change that is influenced by professional knowledge, socio-economic status, and personal characteristics. The effective dissemination of knowledge regards schistosomiasis should be strengthened to emphasize the effectiveness of protective measures against infection and severe disease.

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Spatial Cluster Change of Schistosoma japonicum Transmission Foci in Indonesia During the Schistosomiasis Elimination Program

Nursafingi,

Widjaja,

Widayati

et al. 2024

Acta Parasit.

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Efforts to eliminate schistosomiasis in Hubei province, China: 2005–2018

Cited by 3 publications

References 24 publications

High level of C3 is associated with Th2 immune response and liver fibrosis in patients with schistosomiasis

High level of C3 is associated with Th2 immune response and liver fibrosis in patients with schistosomiasis

Protection motivation theory in predicting intentional behaviors regards schistosomiasis: a WeChat-based qualitative study

Spatial Cluster Change of Schistosoma japonicum Transmission Foci in Indonesia During the Schistosomiasis Elimination Program

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