Effort thrombosis in the lower extremity of a runner

Harvey, John S.

doi:10.1177/036354657800600617

Cited by 21 publications

(8 citation statements)

References 6 publications

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“…This condition is also known as Paget-Schroetter syndrome (6). Similar mechanisms have been reported in case reports concerning the lower extremity (2)(3)(4). An additional factor that may contribute to DVT formation is muscle hypertrophy, leading to compression of venous structures, leading to stasis.…”

Section: Discussionsupporting

confidence: 57%

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Deep Venous Thromboembolism in a Triathlete

Tao

Davenport

2010

The Journal of Emergency Medicine

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Section: Discussionsupporting

confidence: 57%

“…DVT is a diagnosis that should be considered in young, healthy athletes with symptoms, especially after demanding athletic events, despite the fact that it has rarely been reported (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Deep Venous Thromboembolism in a Triathlete

Tao

Davenport

2010

The Journal of Emergency Medicine

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“…41 Additional evidence in support of the association between running and lower limbs DVT is provided by isolated case reports in joggers 42 and longdistance runners. [43][44][45][46][47] Reviewing data on 24 subjects suffering from the so-called coup de fouet syndrome, an uncommon condition characterized by a spontaneous intramuscular venous hemorrhage of the calf often accompanied by DVT of the leg appearing during physical activity (walking, running, and sudden changes of position), Antignani et al detected 10 cases (42%) of gemellar or popliteal vein thrombosis. 48 Remarkably, some cases of exercise-induced retinal vein thrombosis have also been episodically observed.…”

Section: Strenuous Physical Exercisementioning

confidence: 99%

Unsuspected Triggers of Venous Thromboembolism—Trivial or Not So Trivial?

Lippi

Franchini²,

Favaloro³

2009

Semin Thromb Hemost

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Venous thromboembolism (VTE) can be considered a multifactorial disorder involving a variety of inherited and acquired prothrombotic conditions and events. Although greater emphasis has classically been given to traditional thrombophilic risk factors, there is increasing recognition of less typical precipitating conditions and events. Indeed, the list of plausible but unusual triggers of thrombosis includes sneezing and coughing attacks, eating, migraine, sexual intercourse, strenuous physical exercise, drug abuse, and defecation. Although it is difficult to assert conclusively the true contribution of such events to the etiology of acute episodes of venous thrombosis, it seems reasonable to conclude that the concomitant presence of such trivial elements with one or more additional risk factors for VTE might precipitate an acute thrombotic episode.

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“…7 In addition, Kahn et al concluded that early engagement in physical exercise after an acute DVT may not only be safe but also help reduce the risk of developing post-thrombotic syndrome and its long-term adverse consequences. 8 However, several cases of unprovoked VTE, [9][10][11][12][13][14][15][16] and even of acute coronary thrombosis, 17,18 have been described in endurance athletes, suggesting that the effect of high-intensity physical exercise on blood coagulation may not be entirely dismissed. Notably, Hull and Harris identified several putative thrombogenic risk factors in endurance athletes engaged in intensive exercise for long periods of time, including dehydration and hemoconcentration, injury and inflammation, microtrauma to blood vessel walls, immobilization during longdistance travel, use of doping substances with prothrombotic potential, bradycardia and low blood pressure, thoracic outlet obstruction, and May-Thurner syndrome, along with narrowing of inferior vena cava.…”

mentioning

confidence: 99%

Prothrombotic State Induced by Middle-Distance Endurance Exercise in Middle-Aged Athletes

Lippi

Salvagno

Tarperi

et al. 2018

Semin Thromb Hemost

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Since the impact of possible prothrombotic factors on blood coagulation resulting from exercise remains elusive, this study investigated the acute effects of middle-distance endurance running on blood coagulation parameters in middle-aged athletes. The study population consisted of 33 male endurance runners who were engaged in a 21.1 km run under competitive conditions. Blood samples were collected before the run, immediately after the run, and 3 hours after run completion. Samples were assessed for activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen, D-dimer, factor VIII (FVIII), von Willebrand factor antigen (VWF:Ag), endogenous thrombin potential (area under the curve of thrombin generation [TGA-AUC]), and peak thrombin generation (TGA-PK). Post-run variations were expressed as delta (Δ). At baseline, APTT was found to be significantly associated with ABO blood group, VWF:Ag, and FVIII; fibrinogen with age; VWF:Ag with BMI, training regimen, and ABO blood group; APTT with FVIII; FVIII with VWF:Ag and ABO blood group; APTT with VWF:Ag; and TGA-PK with ABO blood group, PT, and TGA-AUC. Immediately after the run, statistically significant increases were observed for PT, D-dimer, VWF:Ag, and FVIII, while statistically significant reductions could be observed for APTT, TGA-AUC, and TGA-PK. Fibrinogen values remained unchanged. Significant correlations were observed between Δ VWF:Ag and Δ FVIII, Δ APTT and Δ VWF:Ag, Δ APTT and Δ FVIII, Δ TGA-AUC and Δ TGA-PK, and between Δ D-dimer and Δ TGA-AUC and Δ TGA-PK. No Δ variation was associated with running time. The results of this study seemingly suggest that middle-distance competitive running may evoke several prothrombotic changes in blood coagulation.

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Effort thrombosis in the lower extremity of a runner

Cited by 21 publications

References 6 publications

Deep Venous Thromboembolism in a Triathlete

Deep Venous Thromboembolism in a Triathlete

Unsuspected Triggers of Venous Thromboembolism—Trivial or Not So Trivial?

Prothrombotic State Induced by Middle-Distance Endurance Exercise in Middle-Aged Athletes

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