Research on effort and motivation commonly measures how the sympathetic branch of the autonomic nervous system affects the cardiovascular system. The cardiac pre-ejection period (PEP), assessed via impedance cardiography, is a common sympathetic outcome, but assessing PEP requires identifying subtle points on cardiac waveforms. The present research examined the value of the RZ interval (RZ), which has recently been proposed as a measure of sympathetic activity, for effort research. Also known as the initial systolic time interval (ISTI), RZ is the time (in ms) between the ECG R peak and the dZ/dt Z peak. Unlike PEP, RZ involves salient waveform points that are easily and reliably identified. Data from two experiments evaluated the suitability of RZ for effort paradigms and compared it to a popular automated PEP method. Participants completed a standard appetitive task in which each correct response earned a small amount of cash. As expected, incentives significantly affected PEP and RZ in both experiments. PEP and RZ were highly correlated (all rs ≥ .89), and RZ consistently yielded a larger effect size than PEP. A quantitative synthesis of the experiments indicated that the effect size of RZ’s response to incentives (Hedges’s g = .432 [.310, .554]) was roughly 15% larger than PEP’s effect size (g = .376 [.256, .496]). RZ thus appears promising for future research on sympathetic aspects of effort-related cardiac activity.