Efflux Pumps in Campylobacter: Key Players for Antimicrobial Resistance and Environmental Adaption

Dai, Lei; Shen, Zhangqi; Yu, Edward; Zhang, Qijing

doi:10.1007/978-3-319-39658-3_18

Cited by 1 publication

(1 citation statement)

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“…Recently, high consumption of antibiotics culminated in the emergence of antibiotic-resistant bacteria. In this regard, several mechanisms are responsible for developing the antibiotic-resistant bacteria (12). RNA efflux pump has an operon coded by three genes of cmeA, cmeB and cmeC which are essential for Campylobacter colonization in the intestinal tract (13).…”

Section: Discussionmentioning

confidence: 99%

The Role of Efflux Pumps in the Antibiotic Resistance of Campylobacter spp. Isolated From Domestic Animals and Poultry

Yousefimanesh

Robati

Piri

et al. 2022

Avicenna J Clin Microbiol Infect

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Background: Chlorhexidine (CHX) is the gold standard chemical agent against oral pathogenic bacteria and is widely used for plaque/gingivitis control. The aim of the present study was to compare the effect of alcohol-based and alcohol-free CHX mouthwashes on oral microorganisms. Methods: In the present in vitro study, the standard strains of four microorganisms present in the oral cavity were prepared, including Streptococcus mutans, Streptococcus sanguinis, Streptococcus salivarius, and Lactobacillus casei. The serial dilutions of CHX antimicrobial agents were obtained, and the level of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was determined using the broth dilution method. Finally, data were analyzed using the Kruskal-Wallis test, the Mann-Whitney U test, and SPSS-16. Results: The MIC values of 0.12% and 0.2% alcohol-free CHX and 0.2% alcohol-based CHX for S. mutans were 1.17, 0.48, and 0.24 µg/mL, respectively. The MBC values of 0.12% and 0.2% alcohol-free CHX and 0.2% alcohol-based CHX for S. mutans were 18.78, 7.81, and 7.81 µg/mL, respectively. The MIC and MBC values of the tested CHX mouthwashes for S. mutans were significant (P≤0.05). Conclusions: Overall, the 0.2% alcohol-based CHX mouthwash had the highest antibacterial activity against gram-positive bacteria.

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Section: Discussionmentioning

confidence: 99%