Efflux of cholesterol and phospholipids derived from the haemoglobin-lipid adduct in human red blood cells into plasma

Nikolić, Milan; Stanić, Dragana; Baricevic, Ivona; Jones, David R.; Nedić, Olgica; Niketić, Vesna

doi:10.1016/j.clinbiochem.2006.11.005

Cited by 15 publications

(12 citation statements)

References 14 publications

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“…Consequently, in copper deficiency changes in the RBC lipid composition are likely (43)(44)(45). Studies of the lipid profile of plasma and membranes of RBCs in copper deficiency support this view.…”

Section: Serum Lipoproteins: Changes In Structure Composition and Dsupporting

confidence: 56%

The Role of Copper as a Modifier of Lipid Metabolism

Burkhead¹,

Lutsenko²

2013

Lipid Metabolism

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Section: Serum Lipoproteins: Changes In Structure Composition and Dsupporting

confidence: 56%

The Role of Copper as a Modifier of Lipid Metabolism

Burkhead¹,

Lutsenko²

2013

Lipid Metabolism

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“…Reports such as these suggest that, in addition to serum cholesterol impacting the population kinetics of erythrocytes and platelets, erythrocytes may reciprocally impact serum cholesterol levels. In support of this postulate, in vitro studies indicate that human erythrocytes act as a reservoir of cholesterol for serum lipoproteins, presumably because of their high nonspecifi c cholesterol loading capacity ( 18,19 ).…”

Section: Discussionmentioning

confidence: 89%

Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population

Fessler

Rose

Zhang

et al. 2013

Journal of Lipid Research

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“…The post - prandial change in cholesterol distribution includes alteration of the blood cell membranes [34,35], which in turn affects microvesiculation. However, differences in the ability of cells from different donors or at different cholesterol levels to vesiculate are probably similar if monitored before, during and directly after MVs isolation.…”

Section: Discussionmentioning

confidence: 99%

Post - prandial rise of microvesicles in peripheral blood of healthy human donors

et al. 2011

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BackgroundMicrovesicles isolated from body fluids are membrane - enclosed fragments of cell interior which carry information on the status of the organism. It is yet unclear how metabolism affects the number and composition of microvesicles in isolates from the peripheral blood.AimTo study the post - prandial effect on microvesicles in isolates from the peripheral blood of 21 healthy donors, in relation to blood cholesterol and blood glucose concentrations.ResultsThe average number of microvesicles in the isolates increased 5 hours post - prandially by 52%; the increase was statistically significant (p = 0.01) with the power P = 0.68, while the average total blood cholesterol concentration, average low density lipoprotein cholesterol concentration (LDL-C) and average high density lipoprotein cholesterol concentration (HDL-C) all remained within 2% of their fasting values. We found an 11% increase in triglycerides (p = 0.12) and a 6% decrease in blood glucose (p < 0.01, P = 0.74). The post - prandial number of microvesicles negatively correlated with the post - fasting total cholesterol concentration (r = - 0.46, p = 0.035) while the difference in the number of microvesicles in the isolates between post - prandial and post - fasting states negatively correlated with the respective difference in blood glucose concentration (r = - 0.39, p = 0.05).ConclusionsIn a population of healthy human subjects the number of microvesicles in isolates from peripheral blood increased in the post - prandial state. The increase in the number of microvesicles was affected by the fasting concentration of cholesterol and correlated with the decrease in blood glucose.

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Efflux of cholesterol and phospholipids derived from the haemoglobin-lipid adduct in human red blood cells into plasma

Cited by 15 publications

References 14 publications

The Role of Copper as a Modifier of Lipid Metabolism

The Role of Copper as a Modifier of Lipid Metabolism

Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population

Post - prandial rise of microvesicles in peripheral blood of healthy human donors

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