Abstract-Since visual attention-based computer vision applications have gained popularity, ever more complex, biologicallyinspired models seem to be needed to predict salient locations (or interest points) in naturalistic scenes. In this paper, we explore how far one can go in predicting eye movements by using only basic signal processing, such as image representations derived from efficient coding principles, and machine learning. To this end, we gradually increase the complexity of a model from simple single-scale saliency maps computed on grayscale videos to spatio-temporal multiscale and multispectral representations. Using a large collection of eye movements on high-resolution videos, supervised learning techniques fine-tune the free parameters whose addition is inevitable with increasing complexity. The proposed model, although very simple, demonstrates significant improvement in predicting salient locations in naturalistic videos over four selected baseline models and two distinct data labelling scenarios.Index Terms-Computational models of vision, video analysis, computer vision, spatio-temporal saliency, eye movement prediction, intrinsic dimension, visual attention, interest point detection.