Efficient trace-scale extraction method of reactor produced ¹⁹⁹Au adequate for nuclear medicine applications

Abstract

Production of no carrier-added (NCA) 199Au through natPt(n, γ) reaction and subsequent purification using liquid-liquid extraction from other radioisotopes is studied in the context of theranostic application. Comparative separation of NCA 199Au after dissolution of activated Pt target using three Cyanex compounds (Cyanex-272, Cyanex-302 and Cyanex-923) is evaluated. The extraction process is optimized in terms of the type of extractant, the concentration of extractant, extraction time and aqueous media (HNO3, NH4OH). Among these extractants, the Cynaex-923 is efficient and promising for rapid separation and production of NCA 199Au from HNO3 by high extraction %. Selective extraction of 199Au from other Pt and Ir radioisotopes is observed. High recovery of 199Au was obtained in the case of Cyanex-923 using 0.05 M thiourea dissolved in HCl or 2 M NaOH. Our results find the Cyanex-923 as a promising extractant for efficient separation of 199Au from irradiated Pt target with high yield (99%).

Purification of Carrier-Free 47Sc of Biomedical Interest: Selective Separation Study from natCa(n,γ)

“…Present study Present study 1 Trioctylphosphine oxide; 2 trialkylbenzylammonium chloride; 3 di-(2-ethylhexyl) phosphoric acid; 4 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester; 5 neodecanoic acid.…”

“…The quality control examination, including radiometric and chemical purities, was carried out as described in [1,2] for the final purified 47 Sc product. The results demonstrated that the produced purified fraction of 47 Sc was free from 47 Ca, with the exception of contributions from 46 Sc and 48 Sc radionuclides, which could only be avoided or reduced to acceptable ratios by irradiating an enriched 46 Ca target.…”

“…Theranostic orientation tools, which integrate both diagnostic and therapeutic applications, have been developed recently that utilize specific radionuclides with the ability to perform both simultaneous functions for the same patient [1][2][3]. In this technique, the selected radionuclides could be a matched pair of the same element or a comparable pair of two different elements [4].…”

“…Separations 2023, 1, x FOR PEER REVIEW 2 of 12 filtration, precipitation, electro-amalgamation, adsorption, and extraction chromatography are applied to radioanalytical chemistry. Ion exchange/adsorption [11,12] and liquid-liquid extraction [1] have been wildly utilized for efficient purification and separation tasks. Several techniques have been developed for the separation and purification of no-carrier-added (NCA) 47 Sc from an irradiated Ca(II) target.…”