Efficient thermal lens nanoparticle detection in a flow-focusing microfluidic device

Yamaoka, Satomi; Kataoka, Yui; Kazama, Yuto; Fujii, Yusaku; Hibara, Akihide

doi:10.1016/j.snb.2016.01.072

Cited by 19 publications

(15 citation statements)

References 33 publications

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“…They found the optimal measurement conditions and proved being able to measure the full TLM signal from 20 consecutive sample flowing volumes (of 0.6 μL) in a minute (thus 20 times/minute). In a similar work, Yamaoka et al [71] have presented a flowfocusing microchip, which together with a TLM allowed the detection of ~ 85% of the polystyrene 500-nm particles injected individually into the chip. The microchip designed by them is shown in Fig.…”

Section: Advances In Tlm and Tlsmentioning

confidence: 99%

Thermal lensing: outside of the lasing medium

Dobek

2022

Appl. Phys. B

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The thermal lens formed in a thermo-optical material as a result of its inhomogeneous heating, is a well-known phenomenon that has found widespread interest in the last decades, especially in the field of laser engineering and photo-thermal spectroscopy. In recent years, growing interest in the application of thermal lensing in different fields of optics and material studies has been observed. This review summarizes the latest efforts made by the scientific community to develop ways of using the phenomenon of thermal lensing. Its applications in spectroscopy, in laser beam formation and in imaging are described. The advantages and disadvantages of the thermal lensing in regard to these areas along with the potential future applications of the phenomenon are discussed.

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Section: Advances In Tlm and Tlsmentioning

confidence: 99%

Thermal lensing: outside of the lasing medium

Dobek

2022

Appl. Phys. B

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“…59 In contrast, TLM finds its niche in detecting nanoparticles, especially for metallic nanoparticles. [60][61][62][63] Imaging static biological samples have been performed using TLM. [64][65][66] TLM may have the potential to detect biological nanoparticles under flow conditions, as the detection principle is not directly linked to the size or refraction index of the analyte.…”

Section: Applicationsmentioning

confidence: 99%

Review of ultrasensitive readout for micro-/nanofluidic devices by thermal lens microscopy

Chen

Shimizu

Kitamori

2021

J. Optical Microsystems

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Thermal lens microscopy (TLM) utilizes the effects, such as changes in the refractive index, caused by heat generated in the sample for the detection of nonfluorescent analytes with at least a hundred-fold enhancement in sensitivity compared with optical absorbance spectrometry. Micro-/nanofluidic devices can provide specificity and sample manipulation capabilities. The integration of these two technologies exposes the potential to attain the holy grail of continuous, real-time, label-free, specific, and ultrasensitive detection, which find applications in environmental monitoring, quality control of chemical manufacturing, single-cell analysis, and biomedicines. Here, we summarize the recent advances in the instrument development and innovative applications, and suggest future directions of research of TLM. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…There are many other optical‐based detection techniques used in microfluidic devices including chemiluminescence , TL detection , surface plasma resonance detection , and surface‐enhanced Raman scattering (SERS) detection . Although these techniques are sensitive, they are not suitable to be used in the microfluidic flow cytometry due to their detection mechanism.…”

Section: Detection In Microfluidic Flow Cytometrymentioning

confidence: 99%

New advances in microfluidic flow cytometry

Gong

Fan

et al. 2018

Electrophoresis

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In recent years, researchers are paying the increasing attention to the development of portable microfluidic diagnostic devices including microfluidic flow cytometry for the point‐of‐care testing. Microfluidic flow cytometry, where microfluidics and flow cytometry work together to realize novel functionalities on the microchip, provides a powerful tool for measuring the multiple characteristics of biological samples. The development of a portable, low‐cost, and compact flow cytometer can benefit the health care in underserved areas such as Africa or Asia. In this article, we review recent advancements of microfluidics including sample pumping, focusing and sorting, novel detection approaches, and data analysis in the field of flow cytometry. The challenge of microfluidic flow cytometry is also examined briefly.

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Efficient thermal lens nanoparticle detection in a flow-focusing microfluidic device

Cited by 19 publications

References 33 publications

Thermal lensing: outside of the lasing medium

Thermal lensing: outside of the lasing medium

Review of ultrasensitive readout for micro-/nanofluidic devices by thermal lens microscopy

New advances in microfluidic flow cytometry

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