Efficient Temperature Sensing Platform Based on Fluorescent Block Copolymer-Functionalized Graphene Oxide

Yang, Hyun-Seung; Paek, Kwanyeol; Kim, Bumjoon J.

doi:10.1039/c3nr01486j

Cited by 46 publications

(51 citation statements)

References 40 publications

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“…3) [49, 50]. The electrolytes including NaCl and MgCl 2 were applied to screen the electrostatic repulsion between the polyanionic DNA and the negatively charged GO at neutral condition, which made DNA close to the GO surface for binding.…”

Section: Resultsmentioning

confidence: 99%

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

et al. 2015

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Stimuli-triggered drug delivery systems are primarily focused on the applications of the tumor microenvironmental or cellular physiological cues to enhance the release of drugs at the target site. In this study, we applied adenosine-5′-triphosphate (ATP), the primary “energy molecule”, as a trigger for enhanced release of preloaded drugs responding to the intracellular ATP concentration that is significantly higher than the extracellular level. A new ATP-responsive anticancer drug delivery strategy utilizing DNA-graphene crosslinked hybrid nanoaggregates as carriers was developed for controlled release of doxorubicin (DOX), which consists of graphene oxide (GO), two single-stranded DNA (ssDNA, denoted as DNA1 and DNA2) and ATP aptamer. The single-stranded DNA1 and DNA2 together with the ATP aptamer serve as the linkers upon hybridization for controlled assembly of the DNA-GO nanoaggregates, which effectively inhibited the release of DOX from the GO nanosheets. In the presence of ATP, the responsive formation of the ATP/ATP aptamer complex causes the dissociation of the aggregates, which promoted the release of DOX in the environment with a high ATP concentration such as cytosol compared with that in the ATP-deficient extracellular fluid. This supports the development of a novel ATP-responsive platform for targeted on-demand delivery of anticancer drugs inside specific cells.

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Section: Resultsmentioning

confidence: 99%

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

et al. 2015

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“…[33][34][35] The δ value is comparable to the values reported previously for other systems involving PNIPAAm brushes on graphene. 13,36 The conjugation of the P7AC-b-PNIPAAm polymers to the surface of the GQDs was confirmed by attenuated total-reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) measurements. As shown in Figure S2a, ATR-FTIR of RAFT-GQDs showed stretching vibrations of the thiocarbonyl group (C=S) at 1072 cm −1 , corresponding to the RAFT agent.…”

Section: Introductionmentioning

confidence: 99%

“…10-12 More importantly, most fluorescent sensors respond to stimuli by a single photoluminescence (PL) intensity change that often requires an expensive PL detector to monitor the response effectively. [13][14][15] Graphene quantum dots (GQDs), nanometer-sized graphene derivatives, have very interesting opto-electronic properties due to quantum confinement and edge effects. [16][17][18][19][20][21] Therefore, in contrast to graphene and graphene oxide that do not exhibit strong stimuliresponsive or luminescent behaviors, GQDs have tunable luminescent properties that depend on their size as well as pH and the presence of metal ions, making them great candidates for a multi-sensing platform.…”

Section: Introductionmentioning

confidence: 99%

“…7-hydroxycoumarin and other materials were purchased from Sigma-Aldrich and N-isopropylacrylamide (NIPAM, 99%) purified by recrystallization in hexane. Deionized (DI) water was used in all experiments.Synthesis of 7-(4-(acryloyloxy)butoxy)coumarin (7AC):The 7AC monomer was synthesized as previously reported 13,58. Anhydrous K2CO3 (3.48 g, 24.8 mmol) was added into a mixture of 7-hydroxycoumarin (2 g, 12.4 mmol) and 1,4-dibromobutane (4.42 mL, 37.2 mmol) in…”

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Multicolor Emitting Block Copolymer-Integrated Graphene Quantum Dots for Colorimetric, Simultaneous Sensing of Temperature, pH, and Metal Ions

et al. 2015

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Highly-selective optical sensors that are capable of detecting complex stimuli have attracted significant interest in environmental, biomedical, and analytical chemistry applications. In this work, we report the development of novel and versatile platform for highly-efficient, colorimetric multi-functional sensors using block copolymer-integrated graphene quantum dots (bcp-GQDs). In particular, the multi-functional sensing behavior is successfully generated simply by grafting blue emitting, temperature-responsive block copolymers onto greenemitting, 10-nm size GQD with the GQD providing luminescent response to pH changes. Thus, the bcp-GQDs showed simultaneous, orthogonal sensing behavior to temperature and pH, as well as dose-dependent responses to different types of metal ions. In addition, the bcp-GQD sensor showed excellent reversibility and dispersion stability in pure water, indicating that our system is an ideal platform for environmental and biological applications. The detailed mechanism of the responsive behavior of the bcp-GQDs was elucidated by measurements of time-resolved fluorescence and dynamic light scattering.

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“…[19][20][21][22][23][24][25] It has received tremendous attention in the past few years, due to its interesting electronic, optical, thermal, mechanical and biomedical properties, as well as water dispersibility. [20][21][22][23][24][25][26][27] Kim and co-workers have reported for the first time a fluorescent, thermally responsive block polymer (P7AC-b-PNIPAM-b-PSN 3 ) functionalized GO sensing system by cycloaddition reaction. Moreover, the surface properties and functionalities of GO can be tailored easily by anchoring nanoparticles and polymers via chemical and physical interactions, such as electrostatic, cycloaddition, hydrophobic, and π-π stacking interactions.…”

Section: Introductionmentioning

confidence: 99%

Temperature responsive polymer brushes grafted from graphene oxide: an efficient fluorescent sensing platform for 2,4,6-trinitrophenol

Song

Liu

et al. 2016

J. Mater. Chem. C

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Thermo-responsive block copolymer brushes of PNIPAM-b-P(MQ-co-GMA) were successfully grafted from graphene oxide (GO) by consecutive reversible addition-fragmentation chain transfer (RAFT) polymerizations based on the monomers of N-isopropylacrylamide (NIPAM), 5-(2-methacryloyl-ethyloxymethyl)-8-quinolinol (MQ) and glycidyl methacrylate (GMA). The 8-hydroxyquinoline units in the polymer brushes could coordinate with Al 3+ to form the green luminescent copolymer brushes containing tris(8-hydroxyquinoline)aluminum (Alq3) on the GO surface. The resulting fluorescent hybrid could be used as a nano-platform for the sensitive and robust detection of 2,4,6-trinitrophenol (TNP). The green fluorescence of the polymer brushes modified GO hybrid in aqueous solution could be quenched by TNP via charge transfer and the observed linear fluorescence intensity change allowed the quantitative detection of TNP with a detection limit down to 2.38×10 -9 M. The fluorescence nanohybrids exhibited a robust temperature-responsive behavior as a result of the conformation change in PNIPAM chains of polymer brushes.

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Efficient Temperature Sensing Platform Based on Fluorescent Block Copolymer-Functionalized Graphene Oxide

Cited by 46 publications

References 40 publications

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

Multicolor Emitting Block Copolymer-Integrated Graphene Quantum Dots for Colorimetric, Simultaneous Sensing of Temperature, pH, and Metal Ions

Temperature responsive polymer brushes grafted from graphene oxide: an efficient fluorescent sensing platform for 2,4,6-trinitrophenol

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