Efficient Synthesis of Unsymmetrical 1,3‐Diynes Utilizing a Palladium‐Catalyzed Cross‐Coupling Reaction Without Homo‐Coupling

Kim, Boyoung; You, Sunyoung; Lee, Nam-Geol; Choi, Sungwook

doi:10.1002/bkcs.10004

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Miscellaneous Metal‐catalyzed Solid‐phase Reactions1

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2022

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Cited by 1 publication

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“…Conjugated 1,3‐diynes play an important role in different areas such as chemistry, biology, and materials science [122] . Professor Choi and co‐workers, [123] have developed an efficient and selective preparation of asymmetric 1,3‐diynes using solid‐phase synthesis.…”

Section: Miscellaneous Metal‐catalyzed Solid‐phase Reactionsmentioning

confidence: 99%

Transition Metal‐Catalyzed Reactions and Solid‐Phase Synthesis: A Convenient Blend

et al. 2022

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Transition metal‐catalyzed, C−C and C−N bond‐forming reactions have made an enormous impact in the way complex molecules are assembled. The benefits of solid‐phase chemistry soon made this type of reaction applicable to solid‐supported processes. In this review, we report the most recent applications and possibilities of this combination. Remarkably, the solid‐phase CuAAC and ring‐closing metathesis have demonstrated an important role in synthetic biology, alike more traditional Pd‐catalyzed reactions, such as Suzuki‐Miyaura, Heck, Sonogashira, which are valuable tools for accessing libraries of biologically relevant small molecules. Examples proved the validity of solid‐phase transition metal‐catalyzed reactions as a practical and fast strategy to cover the current organic chemistry demands.

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Section: Miscellaneous Metal‐catalyzed Solid‐phase Reactionsmentioning

confidence: 99%