Efficient Synthesis of trans‐ or cis‐4(5)‐(5‐Aminomethyltetrahydrofuran‐2‐yl)imidazoles via Diazafulvene Intermediates: Synthetic Approach Toward Human Histamine H4‐Ligands.
Abstract:Furan derivativesFuran derivatives R 0060 Efficient Synthesis of trans-or cis-4(5)-(5-Aminomethyltetrahydrofuran-2-yl)imidazoles via Diazafulvene Intermediates: Synthetic Approach Toward Human Histamine H4-Ligands. -Imifuramine (V), which has potent agonistic activity for the H3-receptor, and analogues, e.g. (VI) and (VII), are prepared by the title approach. -(HARUSAWA, S.; ARAKI, L.; TERASHIMA, H.; KAWAMURA, M.; TAKASHIMA, S.; SAKAMOTO, Y.; HASHIMOTO, T.; YAMAMOTO, Y.; YAMATODANI, A.; KURIHARA*, T.; Chem. Ph… Show more
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