Efficient Synthesis of Polysubstituted Cyclohexene Derivatives by Using Lipase in “Biodegradable Solvent”

Borude, Vasant S.; Shah, Rikhil V.; Shukla, S. R.

doi:10.2174/2211544711201030191

Cited by 3 publications

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“…Whittlesey and co‐workers have synthesized another tri‐nuclear copper complex, bearing a tripodal NHC ligand and an isolated oxygen atom ( 3 , Figure ), which also shows Sonogashira coupling efficiency . Shulka and co‐workers prepared PS‐Cu‐NHC complex 4 (Figure ), a recyclable heterogeneous catalyst, and successfully utilized it in Sonogashira coupling reactions as well . In another recent work, Tahsini and co‐workers investigated the catalytic activity of a series of copper bis‐carbene mononuclear complexes ( 5 , Figure ) in Sonogashira couplings.…”

Section: Introductionmentioning

confidence: 99%

A Sustainable, User‐Friendly Protocol for the Pd‐Free Sonogashira Coupling Reaction

et al. 2018

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We herein present a new catalytic system for the palladium‐free Sonogashira coupling reaction. The catalytically active moiety is formed in situ, in a straightforward and user‐friendly manner, by combining a widely available low‐cost copper salt and an N‐heterocyclic carbene precursor. A series of N‐heterocyclic carbene ligand precursors with variable structural features, some of which are novel, were tested and the reaction conditions were optimized. Using the catalytic system with the optimum performance, the scopes of the alkyne and the aryl halide were probed. Aryl iodides readily react with terminal alkynes, providing the coupling products in high to excellent yields. The protocol is highly efficient with alkynes bearing either alkyl or aryl substituents, the latter having either electron‐donating or electron‐withdrawing groups.

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Section: Introductionmentioning

confidence: 99%

A Sustainable, User‐Friendly Protocol for the Pd‐Free Sonogashira Coupling Reaction

et al. 2018

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“…ILs have been explored in a variety of applications such as organic synthesis, catalysis, biological process developments, extraction, separation and absorption processes, nanomaterial synthesis, electrochemical applications, performance additives for printing inks, etc. .…”

Section: Introductionmentioning

confidence: 99%

Ionic‐liquid‐assisted mixed alkali system for reactive dye fixation in a batch process – optimisation through response surface methodology

Kore

Shukla

2017

Coloration Technology

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An ionic liquid, choline hydroxide, was synthesised and used in a mixed alkali system for fixation of homobifunctional reactive dyes. Its molecular structure was confirmed using FTIR, 1 H NMR, and 13 C NMR spectroscopy. Response surface methodology was employed to optimise the dyeing conditions for reactive dyes using a sodium carbonate-choline hydroxide mixed alkali system. A Box-Behnken design with three variables, namely sodium carbonate concentration, choline hydroxide concentration, and fixation time, was used to design the experimental runs. Analysis of variance was used to estimate the statistical parameters and to evaluate the quality of the statistical model fit. The quality and model terms were evaluated using Fisher's F-test, the coefficient of determination, and probability values. The interactive effect of operating variables on the response (K/S) was studied using three-dimensional response surface plots. The results obtained from the solutions of highest desirability were found to be comparable with conventionally used alkali systems, namely sodium carbonate alone and sodium carbonate-sodium hydroxide mixed alkali. The ionic liquid choline hydroxide could be effectively used along with sodium carbonate for fixation of reactive dyes, with the advantage of reductions in pollution load, total dissolved solids, and chemical oxygen demand. Coloration Technology Society of Dyers and Colourists

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A Decenary Update on the Deep Eutectic Solvents in Heterocyclic Scaffold Synthesis-A Green Solvent Approach

Kamanna

Badiger

Kamath

2023

CGC

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Deep eutectic solvents (DESs) are a mixture of two or more chemicals (hydrogen bond donors and acceptors) that are solid at room temperature, but combined at a unique molar ratio, presenting a melting point recession and becoming liquid. These solvents emerged as an alternative to hazardous solvents employed in various organic transformations and fulfilled the green chemistry concept. The convenience of synthesis, recyclability, inexpensiveness, non-toxicity, high solvent capacity, high biodegradation, low volatile organic character, and environmentally benign nature give DESs an edge over other solvents. Due to the numerous benefits to present environmental concerns and the necessity to replace hazardous solvents, the DESs solvent system is appealing to chemists in recent decades. The most important role played by the DESs showed component interactions via covalent or ionic bonds, and is thus considered a good candidate to replace ionic liquids or traditional solvents. The present review article focuses mainly on recent highlights of DESs, preparation, properties and applications to various heterocyclic molecule construction for the period 2012 to 2022.

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Efficient Synthesis of Polysubstituted Cyclohexene Derivatives by Using Lipase in “Biodegradable Solvent”

Cited by 3 publications

References 0 publications

A Sustainable, User‐Friendly Protocol for the Pd‐Free Sonogashira Coupling Reaction

A Sustainable, User‐Friendly Protocol for the Pd‐Free Sonogashira Coupling Reaction

Ionic‐liquid‐assisted mixed alkali system for reactive dye fixation in a batch process – optimisation through response surface methodology

A Decenary Update on the Deep Eutectic Solvents in Heterocyclic Scaffold Synthesis-A Green Solvent Approach

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