Efficient synthesis of new 6-arylphenanthridines based on microwave-assisted Suzuki–Miyaura cross-coupling and Pictet–Spengler dehydrogenative cyclization in a zinc chloride/[Bmim]BF₄ mixture

Abstract

An ecofriendly, efficient method of synthesis for new pharmacologically active 6-arylphenanthridines has been developed for the first time. The method involves consecutive microwave-assisted Suzuki-Miyaura and Pictet-Spengler processes starting from inexpensive...

A Simple and Effective Protocol for the Pechmann Reaction to Obtain 4-Methylcoumarin Derivatives Using a High-Speed Mixer Ball Mill Process

“…As an important novelty of our research, we carried out coumarins synthesis under solvent-free conditions, using a highspeed mixer ball mill process with a milling frequency of 60 Hz, Teflon ball mill jars, and single stainless-steel balls 8 mm in diameter. Considering the above-stated facts and our constant efforts to study the synthesis of new bioactive small heterocyclic molecules under sustainable reaction conditions [52][53][54][55], we developed a simple green procedure for the synthesis of 4-methylcoumarin derivatives, including 7-amino-4-methylcoumarin This molecule has been considered an important molecule and building block in biophysical research as a common fluorescent probe [56,57].…”