Efficient synthesis of fluorinated biphenyl derivatives via Pd-catalyzed Suzuki coupling reactions in aqueous solvents at room temperature

A novel system for the Suzuki cross-coupling reaction catalysed with light fluorous palladium–NHC complex

“…Also, the coupling reaction could be efficiently executed with aryl boronic acids containing electron-donating and electron-withdrawing groups (Table 3, entries 1, 9 and 10). And the coupling of aryl iodides with phenyl boronic acid gave excellent yields (Table 3, entries [11][12][13][14]. We also performed the reaction with aryl chlorides in our system.…”

“…In general, these reactions were carried out in the presence of a variety of phosphine based ligands [12][13][14]. Lately, N-heterocyclic carbenes (NHCs), as a substitute of phosphorus-containing ligands [15,16], have been introduced as potentially effective ligands for Suzuki cross-coupling reactions.…”

A convenient catalyst system for microwave accelerated cross-coupling of a range of aryl boronic acids with aryl chlorides

“…There has been some interest in the cross-coupling of fluorinated nucleophiles due to the application of fluoroaryl substituents in medicinal chemistry and in liquid crystals. [30-34] The Buchwald group recently reported the first couplings of such substrates with aryl chlorides in high yield. [12] Using our catalyst system, it was pleasing that good yields were also observed with 2 , 3 and 4 substituted fluorophenyl boronic acids but within just 10 minutes of reaction time (Table 1: Entries 6, 8, and 10).…”

Bis(imino)pyridine palladium(II) complexes: Synthesis, structure and catalytic activity

“…In addition, the liquid crystalline materials containing monofluoro-, difluoro-or trifluoro-substituted phenyls [15][16][17][18][19][20] are the most prominent for application in thin-film transistor liquid crys- tal displays (TFT-LCDS). The long, lath-like molecular structure of most fluorinated liquid crystalline compounds demanded by thin-film transistor liquid crystal displays makes Suzuki cross-coupling reactions very important in synthesis.…”