Efficient synthesis of chalcone derivatives catalyzed by re-usable hydroxyapatite

Spectral Correlations and Antimicrobial Activities of some 1-Pyrenyl Chalcones

“…Chalcones possess various biological activities such as antibacterial [26,34], antifungal [26], antioxidant [8], antiviral [9], antimalarial [10], antiplasmodial [28], antituberclosis [12], antiproliferative [13], antileshmanial [14], anti-inflammatory [15], antianalgesic and sedative [16], insect antifeedants [13,22]. Halogenated chalcones possess insect antifeedant activities [13,22,42].…”

“…The Crossed-Aldol [2], Claisen Schmidt [3], Knovenagal [4] and Wittig [5] reactions are important for the synthesis of enones. Many catalyst were used for proceedings the above said reactions namely, EtOH-NaOH [6], MeOH-KOH [7], EtOH-KOH [8], MgCl 2 [5], silica-sulphuric acid [9], anhydrous zinc chloride [10], clay [11], Hydrotalcite [12], ground chemistry catalysts-grinding the reactants with sodium hydroxide [13], aqueous alkali in lower temperature [14], solid sulphonic acid from bamboo [15], barium hydroxide [16] anhydrous sodium bicarbonate [17], microwave assisted synthesis [18], flyash: water [19], fly-ash: H 2 SO 4 [20], fly-ash: PTS [21], NaOH-CTABr [22], SiO 2 -H 3 PO 4 [23], SOCl 2 [24] and sulfated titania [25]. The spectral data of these E-chalcones were useful for prediction of ground state equilibration like s-cis and s-trans conformers.…”

Synthesis of Biologically Active Chalcon Analogues via Claisen-Schmidt Condensation in Solvent-Free Conditions: Supported Mixed Addenda Heteropoly Acid as a Heterogeneous Catalyst

“…Heterogeneous processes are industrially favor catalytic processes in view of the ease of handling, simple work-up and regenerability. There are different kind of catalysts which have been used for the Claisen-Schmidt condensation, including Lewis acids 11 , Brönsted acid 12 , solid acid 13 , solid bases 14 , and other catalysts with more or less success 15,16 . The increasing concern about the tight legislation on the maintenance of greenness in synthetic strategy led us to develop a method using green catalyst that is active in solvent-free conditions as an alternative to volatile organic solvents.…”

Microwave Assisted Sulphated Titania Catalyzed Aldol Condensation: Synthesis of some (<i>E</i>) 3-(2-Naphthyl)-1-(Substituted Phenyl)-2-Propen-1-Ones under Solvent-Free Conditions

“…Many catalysts were applied for synthesis of chalcones using either solvent assisted or solvent-free methods such as EtOH-NaOH [12], MeOH-KOH [13], EtOH-KOH [14], MgCl 2 [15], silica-sulphuric acid [16], anhydrous zinc chloride [17], clay [18], Hydrotalcite [19], ground chemistry catalysts-grinding the reactants with sodium hydroxide [10], aqueous alkali in lower temperature [20], solid sulphonic acid from bamboo [21], barium hydroxide [22] anhydrous sodium bicarbonate [23], microwave assisted synthesis [24], fly-ash:water [25], fly-ash:H 2 SO 4 [26], fly-ash:PTS [27], NaOH-CTABr [11], SiO 2 -H 3 PO 4 [28], SOCl 2 [29] and sulfated titania [30].…”