Efficient Synthesis of 3‐Pyrrolylquinolines via a 1,3‐Dipolar Cycloaddition/Oxidation Sequence.

Abstract

Efficient Synthesis of 3-Pyrrolylquinolines via a 1,3-Dipolar Cycloaddition/Oxidation Sequence. -(MENASRA, H.; KEDJADJA, A.; DEBACHE, A.; RHOUATI, S.; BELFAITAH*, A.; CARBONI, B.; Synth. Commun. 35 (2005) 21, 2779-2788; Lab. Prod. Nat. Orig. Veg., Fac. Sci., Univ. Mentouri-Constantine, Constantine, Algeria; Eng.) -H. Toeppel 15-132

(S)-2-(2-Chloroquinolin-3-yl)-2-[(S)-α-methylbenzylamino]acetonitrile

“…In recent years, we have developed a programme devoted to the synthesis and biological evaluation of quinolyl derivatives (Moussaoui et al, 2002;Kedjadja et al, 2004;Menasra et al, 2004Menasra et al, , 2005Rezig et al, 2000). In a continuation of our efforts in this area, we report here a short and efficient procedure for the preparation of the title -aminonitrile, (2), containing a quinolyl ring system, and its crystal structure determination.…”

(E)-3-(2-Ethoxyquinolin-3-yl)-1-(2-hydroxy-6-methylphenyl)prop-2-en-1-one

“…Molecules of these compounds are conformationally mobile, hence, a series of investigations has been concerned with a study of their three-dimensional structure (Khilya et al, 1991;Bologa et al, 1989;Furmanova et al, 1991). In the course of our ongoing program related to the synthesis and the biological evaluation of new quinoline derivatives (Lalaoui et al, 2003;Menasra et al, 2005;Belfaitah et al, 2006;Bouraiou et al, 2007), we report here the synthesis and crystal structure of the title compound, (I).…”