Efficient synthesis of 2,4-disubstituted thiazoles using ionic liquid under ambient conditions: a practical approach towards the synthesis of Fanetizole

Two New Alkaloids from the Roots of <i>Baphicacanthus cusia</i>

“…On the basis of the comparison of their NMR spectroscopic data with those reported in the literature, the 28 known compounds were identified to be 2-benzoxazolinone (3), 6) tryptanthrin (4), 7) 2-hydroxy-1,4-benzoxazin-3-one (5), 8) 3-(2′-hydroxyphenyl)-4(3H)-quinazolinone (6), 9) 1H-indole-3-carbaldehyde (7), 10) benzouracil (8), 11) 2H-1,4-benzoxazin-3-one (9), 12) 3-carboxyindole (10), 13) acanthaminoside (11), 14) 4(3H)-quinazolinone (12), 15) deoxyvasicinone (13), 16) acanthaminoside isomer (14), 14) lupeol (15), 17) betulin (16), 18) betulinic acid (17), 19) ursolic acid (18), 20) lup-20(29)-en-3β,30-diol (19), 21) maslinic acid (20), 22) guaiacylglycerol-β-ferulic acid ether (21), 23) (2S,3R,4S)-lyoniresinol-3α-O-β-D-glucopyranoside (22), 24) (2R,3S,4R)-lyoniresinol-3α-O-β-D-glucopyranoside (23), 24) (+)-5,5′-dimethoxy-9-O-β-D-glucopyranosyl secoisolariciresinol (24), 25) tyrosol (25), 26) β-hydroxy-benzenepentanoic acid (26), 27) acteoside (27), 28) acteoside isomer (28), 28) loliolide (29), 29) hispiduloside (30). 30) Among these, compounds 3-14 belong to alkaloids (Fig.…”

Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile

“…The formed solid product, in each case, was collected by filtration and re-crystallized from 1,4-dioxane. -4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-3-phenyl-thiazolo [4,5-d]thiazole-2(3H)-thione (7). -To a mixture of compound 1 (2.52 g, 0.01 mol) in 1,4-dioxane (35 mL) containing triethylamine (0.50 mL), elemental sulfur (0.32 g, 0.01 mol) and phenylisothiocyanate (1.35 g, 0.01 mol) were added.…”

“…A number of thiazole derivatives were synthesized according to the Hantzsch thiazole synthesis (1), along with other methods (2)(3)(4)(5)(6)(7). Heterocyclic compounds containing thiazole moiety were found to exhibit a wide spectrum of biological activities such as antioxidant (8), antitubercular (9,10), diuretic (11), antischizophrenia (12), antibacterial (13,14), anti-inflammatory (15), anti-HIV (16), antihypertensive (17), antiallergic (18), hypnotic (19), analgesic (20), antitumor and cytotoxic (21,22).…”

Evaluation and Anti-bacterial Activity of phenyl-2-acetyl- pentafluorobenzoate as Chromones Derivatives

“…These pyrrole derivatives and Chromones are screened for antibacterial activity. It reveals that chromones and pyrazol posses broad spectrum activity such as antimicrobial [1][2][3][4], anti-inflammatory [5], analgesic [6], antitumorial [7], antihypertensive [8], anticonvulsant and antiviral [9]. Since the past few decades, the literature has been enriched with progressive findings about the synthesis and pharmacological activities of various substituted chromones and pyrazol derivatives [10].…”