Efficient Synthesis and Practical Resolution of 1-(Naphthalen-1-yl)ethanamine, a Key Intermediate for Cinacalcet

Efficient Synthesis and Practical Resolution of 1-(Naphthalen-1-yl)ethanamine, a Key Intermediate for Cinacalcet. -A synthesis suitable for large-scale production is given for the hydrochloride salt of (R)-1-(naphthalen-1-yl)ethanamine (V), which is a key intermediate in the synthesis cinacalcet hydrochloride, a drug for the treatment of secondary hyperparathyroidism. -(MATHAD*, V. T.; SHINDE, G. B.; IPPAR, S. S.; NIPHADE, N. C.; PANCHANGAM, R. K.; VANKAWALA, P. J.; Synth. Commun. 41 (2011) 3, 341-346, http://dx.

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ChemInform Abstract: Efficient Synthesis and Practical Resolution of 1‐(Naphthalen‐1‐yl)ethanamine, a Key Intermediate for Cinacalcet.

Mathad

Shinde

Ippar

et al. 2011

ChemInform

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Recent developments in optical resolution

Siedlecka

2013

Tetrahedron

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Deactivation mechanisms of iodo-iridium catalysts in chiral amine racemization

et al. 2021

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Efficient Synthesis and Practical Resolution of 1-(Naphthalen-1-yl)ethanamine, a Key Intermediate for Cinacalcet

Cited by 6 publications

References 5 publications

ChemInform Abstract: Efficient Synthesis and Practical Resolution of 1‐(Naphthalen‐1‐yl)ethanamine, a Key Intermediate for Cinacalcet.

ChemInform Abstract: Efficient Synthesis and Practical Resolution of 1‐(Naphthalen‐1‐yl)ethanamine, a Key Intermediate for Cinacalcet.

Recent developments in optical resolution

Deactivation mechanisms of iodo-iridium catalysts in chiral amine racemization

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