Efficient synthesis and biological evaluation of some new series of pyridine derivatives: Promising and potent new class of anticancer agents

Abstract

In an attempt to develop potent anticancer agents, we have synthesized some substituted pyridine derivatives. Alkylation of the pyridine-3-carbonitrile 1a by chloroacetonitrile or methyl iodide and ethyl iodide produced the O-alkylated nicotinonitrile derivatives (2-4), respectively. The reaction of nicotinonitrile 1a with acetic anhydride furnished the N-acetyl derivative 5. In addition, the reaction of 1a with concentrated sulfuric acid yielded compound 6 whereas its reaction with chloroacetone gave the corresponding 2-alkoxy-pyridine derivative 7 which then refluxed with sodium methoxide to give compound 8. Furthermore, alkylation of 1a-c with methyl bromoacetate and ethyl bromoacetate produced the corresponding methyl, ethyl ester derivatives 9,

Pharmacological Perspectives of 2‐alkoxy‐3‐Cyanopyridine Scaffolds: An Up‐to‐Date Review

“…Abbas and colleagues have reported variously substituted pyridine compounds 8 a – e (Figure 3) to report powerful anticancer drugs for breast, colon, and ovarian cancer [50] . Along with human normal cells EA.…”