“…A common application of metamodels is to substitute the high-fidelity models and therefore increase the speed of the optimization while allowing for a larger set of design points to be considered in the process [30]. In total, metamodels have typically been used to replace complex aerodynamic [31,37,41,46,90,91,94,95,114], as well as structural [31,32,43,51,90,91,95] analyses such as CFD and CSM codes, and it has been shown that this approach can generally be a viable alternative at a minimum loss of accuracy. Similarly, metamodels can also effectively represent other complex elements of the framework, and in fact, they have been successfully implemented to estimate the dynamics of the aircraft systems [83,84], the performance of the engine and the exhaust [12,13,17,51], the noise and the ground boom…”