Efficient Protocol for Novel Hybrid Pyrimidines Synthesis: Antiproliferative Activity, DFT Analyses, and Molecular Docking Studies
Ibrahim O. Althobaiti,
Mjd Saleh Morezeq Alserhani,
Wael A. A. Arafa
et al.
Abstract:An efficient, microwave/ultrasound-irradiated
synthesis of novel
chromenopyrimidines has been established. 2-Amino-5-oxo-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-4
H
-chromene-3-carbonitrile (
1
) underwent cyclization
reactions with various assorted reagents under sustainable conditions
to afford a family of fused pyrimidine derivatives. The proposed structures
of the designed fused pyrimidines were confirmed by several spectral
techniques. Moreover, the targeted pyri… Show more
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