Efficient Prohibitin 2 exposure during mitophagy depends on Voltage-dependent anion-selective channel protein 1
Moumita Roy,
Sumangal Nandy,
Elena Marchesan
et al.
Abstract:Autophagic elimination of depolarized mitochondria (mitophagy) depends on Ubiquitin proteasome complex to expose the inner mitochondrial membrane-resident protein- Prohibitin 2 (PHB2). This uncovering facilitates its interaction with autophagosomal membrane-associated protein LC3. It remains unclear whether PHB2 is uncovered randomly through mitochondrial rupture sites. Prior knowledge and initial screening indicated that Voltage-dependent anion-selective channel protein 1 (VDAC1) might play a role in this pro… Show more
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