Efficient production of l-lactic acid from corncob molasses, a waste by-product in xylitol production, by a newly isolated xylose utilizing Bacillus sp. strain

Wang, Limin; Zhao, Bo; Liu, Bo; Yu, Bo; Ma, Cuiqing; Su, Fei; Hua, Dongliang; Li, Qinggang; Ma, Yanhe; Xu, Ping

doi:10.1016/j.biortech.2010.05.031

Cited by 112 publications

(53 citation statements)

References 35 publications

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“…The recombinant Corynebacterium glutamicum strain produced lactate from xylose under anaerobic conditions, with a yield of 0.54 g/g (9). During our manuscript preparation, Wang et al (23) reported a high concentration, 752 mM (67.7 g/liter), of lactate in batch fermentation by a newly isolated Bacillus sp. strain; however, this product did not show optical purity.…”

mentioning

confidence: 91%

Efficient Homofermentative l -(+)-Lactic Acid Production from Xylose by a Novel Lactic Acid Bacterium, Enterococcus mundtii QU 25

Abdel-Rahman

Tashiro

Zendo

et al. 2011

Appl Environ Microbiol

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mentioning

confidence: 91%

Efficient Homofermentative l -(+)-Lactic Acid Production from Xylose by a Novel Lactic Acid Bacterium, Enterococcus mundtii QU 25

Abdel-Rahman

Tashiro

Zendo

et al. 2011

Appl Environ Microbiol

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“…B. coagulans can metabolize an extensive range of sugars, such as pentoses and hexoses in lignocellulosic biomass (16,17). In contrast to the most frequently used lactic acid producers, such as Lactococcus lactis and Lactobacillus rhamnosus, B. coagulans can grow optimally at 50 to 55°C, a temperature range that is expected to minimize contamination in industrial-scale fermentations under nonsterile fermentation conditions.…”

mentioning

confidence: 99%

Major Role of NAD-Dependent Lactate Dehydrogenases in the Production of l -Lactic Acid with High Optical Purity by the Thermophile Bacillus coagulans

Wang

Cai

Zhu

et al. 2014

Appl Environ Microbiol

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Bacillus coagulans 2-6 is an excellent producer of optically pure L-lactic acid. However, little is known about the mechanism of synthesis of the highly optically pure L-lactic acid produced by this strain. Three enzymes responsible for lactic acid production-NAD-dependent L-lactate dehydrogenase (L-nLDH; encoded by ldhL), NAD-dependent D-lactate dehydrogenase (D-nLDH; encoded by ldhD), and glycolate oxidase (GOX)-were systematically investigated in order to study the relationship between these enzymes and the optical purity of lactic acid. Lactobacillus delbrueckii subsp. bulgaricus DSM 20081 (a D-lactic acid producer) and Lactobacillus plantarum subsp. plantarum DSM 20174 (a DL-lactic acid producer) were also examined in this study as comparative strains, in addition to B. coagulans. The specific activities of key enzymes for lactic acid production in the three strains were characterized in vivo and in vitro, and the levels of transcription of the ldhL, ldhD, and GOX genes during fermentation were also analyzed. The catalytic activities of L-nLDH and D-nLDH were different in L-, D-, and DL-lactic acid producers. Only L-nLDH activity was detected in B. coagulans 2-6 under native conditions, and the level of transcription of ldhL in B. coagulans 2-6 was much higher than that of ldhD or the GOX gene at all growth phases. However, for the two Lactobacillus strains used in this study, ldhD transcription levels were higher than those of ldhL. The high catalytic efficiency of L-nLDH toward pyruvate and the high transcription ratios of ldhL to ldhD and ldhL to the GOX gene provide the key explanations for the high optical purity of L-lactic acid produced by B. coagulans 2-6.

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“…On a commercial scale, LA is currently produced by LA fermentation of sugar-and starch-rich edible crops such as sugar beet, sugar cane, corn and cassava (Harmsen et al, 2014). However, in order to avoid any collision in production of biobased products with food and feed production, the use of alternative feedstocks, such as kitchen garbage (Ačanski et al, 2014), brewer's spent grain (Pejin et al, 2015), corncob molasses (Wang et al, 2010) and other by-products and waste streams has been comprehensively assessed in recent years. The previous study has shown that a waste substrate based on potato stillage and sugar beet molasses could provide valuable nutrients for growth of fastidious lactic acid bacteria (LAB) in batch LA fermentation (Mladenović et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Sugar beet pulp as a carrier for Lactobacillus paracasei in lactic acid fermentation of agro-industrial waste

Mladenović¹,

Djukić‐Vuković²,

Radosavljević³

et al. 2017

J Process Energy Agric

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Efficient production of l-lactic acid from corncob molasses, a waste by-product in xylitol production, by a newly isolated xylose utilizing Bacillus sp. strain

Cited by 112 publications

References 35 publications

Efficient Homofermentative l -(+)-Lactic Acid Production from Xylose by a Novel Lactic Acid Bacterium, Enterococcus mundtii QU 25

Efficient Homofermentative l -(+)-Lactic Acid Production from Xylose by a Novel Lactic Acid Bacterium, Enterococcus mundtii QU 25

Major Role of NAD-Dependent Lactate Dehydrogenases in the Production of l -Lactic Acid with High Optical Purity by the Thermophile Bacillus coagulans

Sugar beet pulp as a carrier for Lactobacillus paracasei in lactic acid fermentation of agro-industrial waste

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