Efficient preparation of substituted 5,6,7,8-tetrahydroquinolines and octahydroacridine derivatives

Abstract

Abstract. The reaction of the enamine 4 with different β-amino ketone hydrochlorides 3a -e affords the diketones 5a -e which can be cyclized to the corresponding mono-and

Novel Phenolic 1-aryl-3-arylamino-1-propanones: Synthesis and Characterization

“…(6). To a mixture of 96% ethanol (4 mL) and water (6 mL) were added 1-(4-bromophenyl)-3-(dimethylamino)propan-1-one hydrochloride 24 (585 mg, 2 mmoles) and 4-aminophenol (218 mg, 2 mmoles), and the mixture was then heated at reflux temperature for one hour. Upon slow cooling to room temperature, a solid separated, and afterwards the mixture was kept in a refrigerator for 3 h. The resulting precipitate was filtered, washed with a mixture of 96% ethanol-water (10 mL, 2:3, v/v), and air-dried.…”