Abstract:Genome editing is almost completely reliant on viral delivery to achieve therapeutic goals, hindering widespread clinical adoption. Chemically defined delivery vehicles such as cationic polymers are versatile alternatives to engineered viruses, but their clinical translation hinges on rapidly exploring vast chemical design spaces and deriving structure-function relationships governing delivery performance. Here, we discovered a polymer for efficient ribonucleoprotein (RNP) delivery through combinatorial polyme… Show more
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