Efficient Phosphodiester Cleaving Nanozymes Resulting from Multivalency and Local Medium Polarity Control

Abstract

The self-organization of Zn(II) complexes on the surface of 1.6-nm diameter gold nanoparticles (nanozymes) allows the spontaneous formation of multiple bimetallic catalytic sites capable to promote the cleavage of a RNA model substrate. We show that by tuning the structure of the nanoparticle-coating monolayer, it is possible to decrease the polarity of the reaction site, and this in turn generates remarkable increments of the cleavage efficiency.

Effects of Noncovalent Interactions on the Catalytic Activity of Unsupported Colloidal Palladium Nanoparticles Stabilized with Thiolate Ligands

“…10–13 Well-developed chemistry to introduce various functional groups and ligands to NPs has been further adopted for the creation of diverse platform for specific biomimetic interactions. 14–20 The biomimetic metal NPs therefore offer a great potential for staging the active part of a large biomolecule with improved stability, which is often a problem for enzymes (denaturation and digestion).…”

Cooperative Effects in Copper Polyamido­amine Dendrimer Complexes Catalyzing the Reduction of Molecular Oxygen

“…For example, Zn 2+ complexes of 1,4,7-triazacyclononane were immobilized on gold nanoparticles for phosphodiester hydrolysis. [14] The dense distribution of Zn 2+ complexes on the nanoparticles improved the reactivity through dimetallic cooperativity.…”

Enantioselective hydrolysis of amino acid esters by non-chiral copper complexes equipped with bis (β-cyclodextrin)s

“…Biomimetic study could help understand the origins of efficiency and specificity of enzymes [5,6]. Introducing supramolecules as the second coordination sphere brings multiple non-covalent interactions to regulate the nature of the metal ion, which was proved to be a promising approach [7][8][9][10][11].…”