Efficient One-Pot Synthesis of Spirooxindole Derivatives by Ethylenediamine Diacetate Catalyzed Reactions in Water

Abstract

A simple and efficient one-pot synthetic approach was used for the preparation of biologically interesting spirooxindole derivatives by means of three-component reactions of isatins, malononitrile, and 1,3-dicarbonyl compounds catalyzed by ethylenediamine diacetate (EDDA) in an aqueous medium. This method is of great value because of its environmentally benign character, high yield, and easy handling.

Sulfonic acid supported on Fe2O3/VO2 nanocatalyst: A highly efficient and reusable nanocatalyst for synthesis of spirooxindole derivatives

“…[BMIm]BF4 [18], L-proline [19], ethylenediaminediacetate [20], indium chloride (InCl3) [21], triethyle amine (NEt3) [22], electrogenerated base (NaBr/ROH) [23], cyclodextrin [24], and surfactant metal carboxylates [25] have been studied till now. Although a variety of methods and catalyst are available, some of them have disadvantages such as, harsh reaction conditions, long reaction times, and use of expensive, unsafe, and unreusable catalysts.…”