“…For the time being, we will consider the model with dynamic boundary conditions and the bulk-surface problem in a spherical domain, but the proposed methods can be extended to domains with more general geometry in 3D (and the main ideas of the algorithms will stay the same, see Remark 5 below). We employ a finite-difference scheme for the underlying space discretization of the models in the bulk (1) or ( 4), combined with the idea of Difference Potentials Method (DPM) ( [33] and very recent work [2,3,17,18,32], etc.) that provides flexibility to handle irregular domains and nontrivial boundary conditions (including, but not limited to, dynamic boundary conditions like (2), or surface equations like (6)) accurately and efficiently.…”