“…Therapeutic US-mediated MB destruction have already been applied in a multitude of ways, including delivery of DNA, siRNA [19–21], drugs [7, 22], stem cells [23] to different cell types such as tumor [24, 25], cardiovascular [26, 27], and skeletal muscle [1, 28], and organs such as liver [16–18], brain [2, 3, 22], and kidney [29, 30]. Given that the effectiveness of MBs depends on several variables such as their acoustic behaviors, size, stability, and compositions [31, 32], it is imperative to generate MBs that are tailored for their specific functions, instead of using generic MBs, such as the commercially available Definity ® that is approved as a contrast agent for echocardiographic imaging.…”