Efficient mesenchymal stem cell conversion to corneal keratocytes by the use of specific biomaterial and Cell Rev™ mSC diffKera media

Koh, Hyun‐Moo; Sirivisoot, Sirinrath; Talchai, S.; Khemarangsan, V.

doi:10.1016/j.jcyt.2020.03.383

Cited by 1 publication

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“…Recently, it was shown that the efficiency of cell differentiation probably depends on the biomaterials used and the composition of the cultured medium. The closer the environment resembles the human cornea, the higher the likelihood that most of the MSCs differentiate into corneal keratocytes [62]. Therefore, some authors have proposed the modulation of tissue biomechanics (e.g., substrate stiffness) as a pharmacological method for modulating the phenotype of cells, initiating novel prospects for establishing more successful cell therapies and medical devices for cornea tissue regeneration [63].…”

Section: Modulation Of Cell Behavior By Cornea Te Graftsmentioning

confidence: 99%

Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration

et al. 2021

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Nowadays, tissue engineering is one of the most promising approaches for the regeneration of various tissues and organs, including the cornea. However, the inability of biomaterial scaffolds to successfully integrate into the environment of surrounding tissues is one of the main challenges that sufficiently limits the restoration of damaged corneal tissues. Thus, the modulation of molecular and cellular mechanisms is important and necessary for successful graft integration and long-term survival. The dynamics of molecular interactions affecting the site of injury will determine the corneal transplantation efficacy and the post-surgery clinical outcome. The interactions between biomaterial surfaces, cells and their microenvironment can regulate cell behavior and alter their physiology and signaling pathways. Nanotechnology is an advantageous tool for the current understanding, coordination, and directed regulation of molecular cell–transplant interactions on behalf of the healing of corneal wounds. Therefore, the use of various nanotechnological strategies will provide new solutions to the problem of corneal allograft rejection, by modulating and regulating host–graft interaction dynamics towards proper integration and long-term functionality of the transplant.

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Section: Modulation Of Cell Behavior By Cornea Te Graftsmentioning

confidence: 99%