Efficient induction of anti-tumor immune response in esophageal squamous cell carcinoma via dendritic cells expressing MAGE-A3 and CALR antigens

Liu, Xinli; Song, Na; Liu, Yu; Liu, Yang; Li, JiJia; Ding, Jianqiao; Tong, Zhuang

doi:10.1016/j.cellimm.2015.03.011

Cited by 17 publications

(8 citation statements)

References 23 publications

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“…With the application and development of surgery, chemotherapy, and immunotherapy, the prognosis for patients with ESCC has markedly improved. However, five-year survival rates for patients with ESCC remain low at ~10%, due to the invasive and metastatic potential of ESCC (3,4). Earlier diagnosis of ESCC may reduce the probability of tumor cell metastasis and markedly improve the prognosis of patients (5,6).…”

Section: Introductionmentioning

confidence: 99%

Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma

Zhang

Dong

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to determine the expression levels and biological functions of in patients with esophageal squamous cell carcinoma (ESCC). A total of 60 patients with ESCC and 30 healthy individuals were enrolled and reverse transcription-quantitative polymerase chain reaction was performed to measure the expression levels of miR-202. In order to investigate the effects of miR-202 expression levels on the proliferative, migratory and invasive abilities of ESCC cells, methylthiazolyl-tetrazolium bromide proliferation, in vitro scratch and Transwell ® chamber assays were performed. Expression levels of miR-202 were significantly decreased in the peripheral blood of patients with ESCC, which is associated with the degree of cell differentiation and lymph node metastasis (P<0.05). Following miR-202 transfection, cell proliferation was significantly inhibited (P<0.05). Cell migration and invasion was also significantly inhibited by miR-202 transfection (P<0.05). The results of the present study demonstrated that the expression of miR-202 inhibited the proliferation, migration and invasion of ESCC cells. Furthermore, low expression levels of miR-202 were detected in the peripheral blood of patients with ESCC, which is associated with the development, invasion and metastasis of ESCC.

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Section: Introductionmentioning

confidence: 99%

Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma

Zhang

Dong

et al. 2016

Experimental and Therapeutic Medicine

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“…IL‐10, a typical Treg cytokine, is often used to predict immune tolerance induced by DCs, while IL‐12p70 is important for the development of Th1 responses and cell‐mediated immunity. The suppression of IL‐10 and induction of IL‐12 were important for effective immunotherapy by targeting to DC maturation . Therefore, the ratio of IL‐12p70/IL‐10 was used as a predictor for immune activation.…”

Section: Resultsmentioning

confidence: 99%

Microneedle-Assisted, DC-Targeted Codelivery of pTRP-2 and Adjuvant of Paclitaxel for Transcutaneous Immunotherapy

Jin

et al. 2017

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This work aims at developing an immunotherapeutic strategy to deliver a cancer DNA vaccine targeting dendritic cells (DCs), to trigger their maturation and antitumor function, and reduce immune escape using a polymeric nanocomplex of paclitaxel (PTX)-encapsulated sulfobutylether-β-cyclodextrin (SBE)/mannosylated N,N,N-trimethylchitosan (mTMC)/DNA. To enhance DC-targeting and revoke immunosuppression is the major challenge for eliciting effective antitumor immunity. This codelivery system is characterized by using low-dose PTX as an adjuvant that is included inside SBE, and the PTX/SBE further serves as an anionic crosslinker to self-assemble with the cationic mTMC/DNA polyplexes. This system is used in combination with a microneedle for transcutaneous vaccination. Once penetrating into the epidermis, the mannosylated nanocomplexes would preferentially deliver the pTRP-2 DNA vaccine inside the DCs. Phenotypic maturation is demonstrated by the increased expression of costimulatory molecules of CD80 and CD86, and the elevated secretion of IL-12p70. The mixed leucocyte reactions reveal that the PTX/SBE-mTMC/DNA nanocomplexes enhance the proliferation of CD4+ and CD8+ T cells, and inhibit the generation of immune-suppressive FoxP3+ T cells. The system shows high antitumor efficacy in vivo. The PTX/SBE-mTMC/DNA nanocomplexes for DC-targeted codelivery of DNA vaccine and adjuvant PTX yield synergistic effects on the DC maturation and its presenting functions, thus increasing immune stimulation and reducing immune escape.

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“…P46940 (IQGAP1) has been associated with poor prognosis in head and neck squamous cell carcinoma (41) and has also been associated with response to chemo-radiotherapy in rectal adenocarcinomas (42). P27797 (CALR) induces an immune response in esophageal squamous cell carcinoma (43). P08133 (ANXA6) promotes EGFR deactivation (44).…”

Section: Discussionmentioning

confidence: 99%

Genetic Profile and Functional Proteomics of Anal Squamous Cell Carcinoma: Proposal for a Molecular Classification

Trilla-Fuertes¹,

Ghanem

Gámez‐Pozo

et al. 2020

Molecular & Cellular Proteomics

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Anal squamous cell carcinoma is a rare tumor. Chemo-radiotherapy yields a 50% 3-year relapse-free survival rate in advanced anal cancer, so improved predictive markers and therapeutic options are needed. High-throughput proteomics and whole-exome sequencing were performed in 46 paraffin samples from anal squamous cell carcinoma patients. Hierarchical clustering was used to establish groups de novo. Then, probabilistic graphical models were used to study the differences between groups of patients at the biological process level. A molecular classification into two groups of patients was established, one group with increased expression of proteins related to adhesion, T lymphocytes and glycolysis; and the other group with increased expression of proteins related to translation and ribosomes. The functional analysis by the probabilistic graphical model showed that these two groups presented differences in metabolism, mitochondria, translation, splicing and adhesion processes. Additionally, these groups showed different frequencies of genetic variants in some genes, such as ATM, SLFN11 and DST. Finally, genetic and proteomic characteristics of these groups suggested the use of some possible targeted therapies, such as PARP inhibitors or immunotherapy.

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Efficient induction of anti-tumor immune response in esophageal squamous cell carcinoma via dendritic cells expressing MAGE-A3 and CALR antigens

Cited by 17 publications

References 23 publications

Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma

Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma

Microneedle-Assisted, DC-Targeted Codelivery of pTRP-2 and Adjuvant of Paclitaxel for Transcutaneous Immunotherapy

Genetic Profile and Functional Proteomics of Anal Squamous Cell Carcinoma: Proposal for a Molecular Classification

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