Efficient immobilization of firefly luciferase in a metal organic framework: Fe-MIL-88(NH2) as a mighty support for this purpose

Pickering Emulsion-Based Microreactors for Size-Selective Interfacial Enzymatic Catalysis

“…In recent years, metal-organic frameworks (MOFs), a kind of porous crystalline organic-inorganic hybrid materials, composing of inorganic metal ions or metal clusters and organic ligands, have emerged as an excellent carrier for enzyme immobilization because of their fascinating physicochemical properties like thermal stability, high-surface area, pore size selectivity, and biocompatibility (Tan et al, 2019;Zhao et al, 2019;Zhou et al, 2019). Several approaches including physical adsorption (Nobakht et al, 2018;Jia et al, 2019), covalent bonding (Yue et al, 2016;Nowroozi-Nejad et al, 2019), and biomimetic mineralization (Liang et al, 2015;Jiang et al, 2017) have been employed to immobilize enzymes into MOFs. Among these methods, physical adsorption relies on numerous weak interactions (e.g., electrostatic interactions, hydrogen bonding, and van der Waals forces) between enzyme molecules and MOF crystals (Drout et al, 2019), thus adsorbed enzymes usually reveal poor stability in a harsh environment.…”

Removal of anthracene in water by MIL-88(Fe), NH2-MIL-88(Fe), and mixed-MIL-88(Fe) metal–organic frameworks

“…34,35 They possessed high surface area with a large number of pores (free volumes constituted about 90% of the frameworks). 36,37 The diversity of the framework, the variability of the metal nodes, chemical stability and tunability of the materials coupled with the porous nature makes MOFs unique materials in comparison to other coordination polymers. Thus, they constituted a new discipline of science; known as Isoreticular Chemistry.…”

Versatile Nanoscale Metal–Organic Frameworks (nMOFs): An Emerging 3D Nanoplatform for Drug Delivery and Therapeutic Applications

“…So far, various nMOFs have been constructed using this mature method, including MIL‐88B(Fe), MIL‐101‐NH 2 (Fe), and azide‐functionalized UiO‐66‐N 3 . [ 30 ] Further, in order to avoid the toxicity of organic solvents, more attempts have been devoted to prepare nMOFs with water, called “green synthesis.” With such concept, MIL‐100, MIL‐100(Fe), and ZIF‐8 were successfully produced via hydrothermal method. [ 31 ]…”

“…reported that acetic acid acted as a growth inhibitor during the synthesis of MIL‐88(Fe) in dimethylformamide solution, exerting a powerful effect on the particle size and aspect ratio of MIL‐88. [ 30a ] Similarly, Liu and coworkers employed nontoxic poly(allylamine hydrochloride) to precisely modulate the size of monodispersed ZIF‐8 (30–150 nm) under aqueous environment. [ 32 ] This water‐soluble cationic polymer could compete with the imidazole ligands to coordinate zinc ions, which contributed to slowing down the nucleation rate and accordingly yielding larger particles.…”