Efficient generation of CAR NK cells from human umbilical cord blood CD34+stem and progenitors for democratizing affordable immunotherapy
Jianhuan Li,
Yao Wang,
Xiujuan Zheng
et al.
Abstract:Chimeric antigen receptor (CAR) natural killer cells (CAR NK) cells, leveraging safety and not requiring HLA match in adoptive infusion, have emerged as promising alternative cells to CAR-T cells for immunotherapies. High and multiple doses of CAR NK cell infusions are essential to maintain therapeutic efficacy in clinical trials. This requires efficient methods for generating large-scale CAR NK cells and significantly reducing CAR engineering costs. In this study, we develop a three-step strategy to generate … Show more
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