Efficient Fermentative Production of d-Alanine and Other d-Amino Acids by Metabolically Engineered Corynebacterium glutamicum
Siyu Tian,
Guihong Zhao,
Gengcheng Lv
et al.
Abstract:D-Amino acids (D-AAs) have wide applications in industries such as pharmaceutical, food, and cosmetics due to their unique properties. Currently, the production of D-AAs has relied on chemical synthesis or enzyme catalysts, and it is challenging to produce D-AAs via direct fermentation from glucose. We observed that Corynebacterium glutamicum exhibits a remarkable tolerance to high concentrations of D-Ala, a crucial characteristic for establishing a successful fermentation process. By optimizing mesodiaminopil… Show more
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