Efficient extraction of flavonoids from Flos Sophorae Immaturus by tailored and sustainable deep eutectic solvent as green extraction media

Wang, Gen; Cui, Qi; Yin, Lujun; Zheng, Xue; Gao, Ming‐Zhu; Meng, Yao; Wei, Wang

doi:10.1016/j.jpba.2018.12.032

Cited by 61 publications

(34 citation statements)

References 27 publications

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“…For the recovery of the extracted bioactive compounds, in particular the flavonoids, there are several approaches such as solid phase extraction (SPE) [47,164], macroporous resin adsorption [79,103,111,143,144,148], anti-solvent precipitation [107,164,165], back-extraction [122], and adsorption chromatography [166] that have been evaluated to date.…”

Section: Recovering Of the Bioactive Compounds From The Des/nades Extmentioning

confidence: 99%

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

120

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The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.

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Section: Recovering Of the Bioactive Compounds From The Des/nades Extmentioning

confidence: 99%

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

120

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“…To sum up, 70% ethanol concentration was chosen as subsequent experiments. RU, NI, and NA are flavonoid glycosides with the larger polarity, and QU, KA, and IS are the corresponding flavonoid aglycones of the former, respectively, and their polarity is relatively small [15]. They are all planar molecules with tight molecular packing, large inter molecular attraction, and more hydrophilic hydroxyl groups, so the solubility in water is not large.…”

Section: Effects Of the Ethanol Concentration On Uaementioning

confidence: 99%

“…At present, simultaneous extraction of several flavonoids' compounds from FSI have been reported, as described in Table 1. Gen Wang et al optimized the extraction conditions of RU, NI, NA, KA, IS, and QU from FSI by deep eutectic solvent (DES) using microwave-assisted extraction (MAE) [15]. In Jin-Liang Liu et al s study, they optimized the extraction process of RU, KA, IS, QU, and genistein from FSI by methanol using MAE [16].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have reported the extraction flavonoids from FSI using ethanol, methanol, DES, ionic liquids (ILs), and 1-butyl-3-methylimidazoliumchloride (BMIM-Cl) solution, as shown in Table 1. However, methanol is neurotoxic, the preparation of ILs is more difficult and DES and BMIM-Cl in the laboratory research stage and cannot be mass-produced [15,25]. Therefore, an environment-friendly and efficient method to extract flavonoids from FSI is very important.…”

Section: Introductionmentioning

confidence: 99%

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Optimization of Ultrasound-Assisted Extraction Using Response Surface Methodology for Simultaneous Quantitation of Six Flavonoids in Flos Sophorae Immaturus and Antioxidant Activity

et al. 2020

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Ultrasound-assisted extraction (UAE) was applied to extract rutin (RU), nicotiflorin (NI), narcissoside (NA), kaempferol (KA), isorhamnetin (IS), quercetin (QU), and total flavonoids of Flos Sophorae Immaturus (TFFSI) from Flos Sophorae Immaturus (FSI). Through single factor test and response surface methodology (RSM), the optimal extraction conditions were concluded as follows: ethanol concentration 70%, time 30 min, temperature 61 °C, and liquid/solid ratio 15.30 mL/g, respectively. The actual extraction rates of RU, NI, NA, KA, IS, QU, and TFFSI were 14.6101%, 2.9310%, 7.1987%, 0.1041%, 0.4920%, 2.7998%, and 26.4260%, respectively. The experimental results demonstrated that the extraction method with accuracy and efficiency could be used for the comprehensive evaluation quality control of extracts from FSI. The antioxidant activities of hydroalcoholic extraction from FSI on 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+), superoxide anion (•O2−) free radicals, and ferric reducing/antioxidant power (FRAP) were assessed. The results showed that the antioxidation activities of extracts on DPPH, ABTS•+, and •O2− free radicals were reached 89.29%, 97.86%, and 56.61%, and 81.4% in FRAP at 1.0 mg/mL, respectively. The antioxidant capacity of FSI extract was positively correlated with the amount of total flavonoids.

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“…In recent years, DESs have been proved to be efficient solvents to extract natural products such as flavonoids [46][47][48], isoflavonoids [49], phenolic compounds [2], phenolic acids [50], terpenoids [18], and alkaloids [51,52] from plant materials. As a new type of green extractant, effective extraction of hazard residues by DESs is critical to ensuring the environment and consumer safety.…”

Section: Deep Eutectic Solvents As the Alternative Extraction Solventmentioning

confidence: 99%

Development and applications of deep eutectic solvent derived functional materials in chromatographic separation

Liu

Wang

et al. 2020

J of Separation Science

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Deep eutectic solvents have received increasing attention over the past decade, and the green and versatile nature makes them important media for developing environmentally friendly and sustainable technologies. In addition to act as green alternatives to traditional organic solvents, deep eutectic solvents offer tremendous opportunities to produce different kinds of emerging functional materials. The present review highlights the recent development and applications of deep functional materials based on deep eutectic solvents as novel adsorbents for diverse analytes in complex matrices. The type, preparation, and unique properties of deep eutectic solvents, the synthesis of deep eutectic solvent derived materials, as well as their applications in chromatographic separation are described. We aim to demonstrate that deep eutectic solvents not only allow the design of eco-friendly extraction processes but also open straightforward access to advanced materials in sample preparation.

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Efficient extraction of flavonoids from Flos Sophorae Immaturus by tailored and sustainable deep eutectic solvent as green extraction media

Cited by 61 publications

References 27 publications

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Optimization of Ultrasound-Assisted Extraction Using Response Surface Methodology for Simultaneous Quantitation of Six Flavonoids in Flos Sophorae Immaturus and Antioxidant Activity

Development and applications of deep eutectic solvent derived functional materials in chromatographic separation

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